Journal Article10.1007/S00103-016-2505-6
Ein Vitamin mit zwei Gesichtern: Folsäure – Prävention oder Promotion von Dickdarmkrebs?
About: This article is published in Bundesgesundheitsblatt-gesundheitsforschung-gesundheitsschutz. The article was published on 01 Mar 2017.
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References
Colorectal cancer in inflammatory bowel disease: Results of the 3rd ECCO pathogenesis scientific workshop (I)
Shaji Sebastian,Vincent Hernández,Pär Myrelid,Revital Kariv,Epameinondas V. Tsianos,Murat Törüner,Marc Marti-Gallostra,Antonino Spinelli,Andrea E. van der Meulen-de Jong,Elif Sarıtas Yuksel,Christoph Gasche,Sandro Ardizzone,Silvio Danese +12 more
TL;DR: A detailed literature review was conducted on epidemiology, risk factors, pathophysiology, chemoprevention and outcomes of colorectal cancer (CRC) in IBD as part of the 3rd ECCO scientific pathogenesis workshop.
Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review.
Emanuela Taioli,M. A. Garza,Yoon Ok Ahn,D. T. Bishop,J. Bost,B. Budai,K. Chen,Federica Gemignani,Temitope O. Keku,Carmen Silvia Passos Lima,Loic Le Marchand,Keitaro Matsuo,Victor Moreno,J. Plaschke,Maria Pufulete,Stephen B. Thomas,Giuseppe Toffoli,C. R. Wolf,Charity G. Moore,Julian Little +19 more
TL;DR: In this paper, the authors performed both a meta-analysis (29 studies; 11,936 cases, 18,714 controls) and a pooled analysis (14 studies; 5,068 cases, 7,876 controls), with stratification by racial/ethnic population and behavioral risk factors.
Pre- and postfortification intake of folate and risk of colorectal cancer in a large prospective cohort study in the United States
Todd M. Gibson,Stephanie J. Weinstein,Ruth M. Pfeiffer,Albert R. Hollenbeck,Amy F. Subar,Arthur Schatzkin,Susan T. Mayne,Rachael Z. Stolzenberg-Solomon +7 more
TL;DR: Folate intake was associated with a decreased colorectal cancer risk in the NIH-AARP Diet and Health Study, a US cohort study of 525,488 individuals aged 50-71 y initiated in 1995-1996, and no significant differences between time periods were observed.
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Folate Deficiency Induces Genomic Uracil Misincorporation and Hypomethylation But Does Not Increase DNA Point Mutations
Heinz G. Linhart,Aron M. Troen,George W. Bell,Erika Cantu,Wei–Hsun Chao,Eva Moran,Eveline J. Steine,Timothy He,Rudolf Jaenisch +8 more
TL;DR: Findings indicate that the effects of a low-folate diet on DNA methylation and point mutations are insufficient to promote tumor development, even in the presence of Ung deficiency.
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