EGF receptor trafficking: consequences for signaling and cancer.
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TL;DR: This data indicates that EGF receptor endocytic traffic can regulate signaling and cell survival and EGFR traffic promoted by antineoplastic therapy is important in tumor resistance.
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About: This article is published in Trends in Cell Biology. The article was published on 01 Jan 2014. and is currently open access. The article focuses on the topics: Epidermal growth factor receptor.
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Citations
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YAP and TAZ: a nexus for Hippo signaling and beyond.
TL;DR: The function of Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ) and their role as a signaling nexus and integrator of several other prominent signaling pathways such as the Wnt, G protein-coupled receptor (GPCR), epidermal growth factor (EGF), bone morphogenetic protein (BMP)/transforming growth factor beta, and Notch pathways are discussed.
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References
EGF receptor ubiquitination is not necessary for its internalization.
TL;DR: Interestingly, the reconstitution of two major ubiquitination sites in the 16KR receptor mutant, which had impaired kinase activity and slow internalization kinetics, resulted in a partial rescue of ubiquitinated and a complete rescue of receptor internalization, suggests that ubiquitinations of the kinase-impaired receptor can mediate its internalization by the clathrin pathway.
COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport
Ying Nai Wang,Hongmei Wang,Hirohito Yamaguchi,Hong Jen Lee,Hong Jen Lee,Heng Huan Lee,Mien Chie Hung +6 more
TL;DR: These findings experimentally provide a comprehensive pathway that nuclear transport of EGFR is regulated by COPI-mediated vesicular trafficking from the Golgi to the ER, and may serve as a general mechanism in regulating thenuclear transport of other cell surface receptors.
Imaging Sites of Receptor Dephosphorylation by PTP1B on the Surface of the Endoplasmic Reticulum
TL;DR: Most of the RTKs activated at the cell surface showed interaction with PTP1B after internalization, establishing that RTK activation and inactivation are spatially and temporally partitioned within cells.
The caveolae membrane system.
Richard G. W. Anderson
TL;DR: Caveolae constitute an entire membrane system with multiple functions essential for the cell and are capable of importing molecules and delivering them to specific locations within the cell, exporting molecules to extracellular space, and compartmentalizing a variety of signaling activities.
The EGFR inhibitor gefitinib suppresses ligand-stimulated endocytosis of EGFR via the early/late endocytic pathway in non-small cell lung cancer cell lines.
TL;DR: Novel evidence is provided that efficient endocytosis of EGF–EGFR occurs via the endocytic pathway in the PC9 cells, because the internalized Texas red-EGF-positive small punctate vesicles were transported to the late endosomes/lysosomes and then degraded within the lysosomes after 60 min of internalization.