EGF receptor trafficking: consequences for signaling and cancer.
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TL;DR: This data indicates that EGF receptor endocytic traffic can regulate signaling and cell survival and EGFR traffic promoted by antineoplastic therapy is important in tumor resistance.
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About: This article is published in Trends in Cell Biology. The article was published on 01 Jan 2014. and is currently open access. The article focuses on the topics: Epidermal growth factor receptor.
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Citations
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References
Regulation of the Ligand-dependent Activation of the Epidermal Growth Factor Receptor by Calmodulin
Hongbing Li,Svetlana Panina,Amandeep Kaur,María José Ruano,Pablo Sánchez-González,Jonas M. la Cour,Alexander Stephan,Uffe H. Olesen,Martin W. Berchtold,Antonio Villalobo +9 more
TL;DR: The hypothesis that Ca2+/CaM regulates the EGFR activity by directly interacting with the CaM-BD of the receptor located at its cytosolic juxtamembrane region is supported.
40
Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells
TL;DR: The elucidation of new SFK targets like Odin in epithelial cancer cells is expected to lead to novel insight into cancer cell signalling mechanisms and may also serve to indicate new biomarkers for monitoring tumor cell responses to drug treatments.
EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins.
TL;DR: The EGfrvIII does not transform by escaping regulation by Cbl proteins and this activation-induced downregulation of the EGFRvIII has an important role in mediating the toxicity of anti-EGFRv III immunotoxins.
37
Differential roles of Grb2 and AP-2 in p38 MAPK- and EGF-induced EGFR internalization.
Michael Vibo Grandal,Lene Melsæther Grøvdal,Lasse Henriksen,Mette H. Andersen,Mikkel R. Holst,Mikkel R. Holst,Inger H. Madshus,Bo van Deurs +7 more
TL;DR: It seems that EGFR in the two situations uses different sets of internalization mechanisms, as both types of endocytosis require clathrin and p38 MAPK‐induced internalization did not.
33
Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH.
TL;DR: Endosomal recycling of the EGFR and ErbB2 receptors is associated with significantly impaired tyrosine phosphorylation of the ESCRT-0 subunit Hrs as well as decreased deubiquitination by AMSH, which is consistent with the finding that recycling receptors are not efficiently incorporated in the MVB pathway.
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