Journal Article10.1080/10406638.2022.2074475
Efficient Synthesis of Substituted Aza-Anthraquinones via Michael Addition–Elimination and Intramolecular Cyclization Reactions under Mild Conditions and Their Fluorescent Properties
TL;DR: In this article , the SnCl2 catalyzed reaction of 2-amino-4H-chromen-4-one with 2-benzylidenemalononitriles provides the corresponding substituted aza-anthraquinone analogs via a Michael addition-elimination followed by intramolecular cyclization.
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About: This article is published in Polycyclic Aromatic Compounds. The article was published on 23 May 2022. The article focuses on the topics: Chemistry & Michael reaction.
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References
Anti-cancer properties of anthraquinones from rhubarb.
TL;DR: Re‐evaluation of an old remedy suggests that several bioactive anthraquinones of rhubarb possess promising anti‐cancer properties and could have a broad therapeutic potential.
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Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.
Sanjeev Kumar,William P. Malachowski,James B. DuHadaway,Judith M. LaLonde,Patrick J. Carroll,Daniel Jaller,Richard Metz,George C. Prendergast,Alexander J. Muller +8 more
TL;DR: Genetic validation that IDO is the critical in vivo target is demonstrated using IDO-null mice and a new class of naphthoquinone-based IDO inhibitors exemplified by the natural product menadione is defined, shown in mouse tumor models to have similar antitumor activity to previously characterized IDO abusers.
170
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Lei Zhang,Lei Zhang,Shelly Hogan,Jianrong Li,Shi Sun,Corene Canning,Shao Jian Zheng,Kequan Zhou,Kequan Zhou +8 more
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Antiprotozoal and cytotoxic naphthalene derivatives from Diospyros assimilis
TL;DR: The naphthalene derivatives 1-5 were evaluated for their in vitro antiprotozoal activity against protozoan parasites belonging to the genera Trypanosoma, Leishmania and Plasmodium and showed moderate inhibition of the growth of the parasites, T. brucei, L. donovani and L. cruzi.
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