Effects of bleomycin on mouse transplantable tumors
Mieko Takeuchi,Tadashi Yamamoto +1 more
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TL;DR: The present paper briefly considers the effect of a new antitumor antibiotic, bleomycin1), on several strains of transplantable mouse ascites tumors, all of which were originally established as syngeneic in tumor-host relationship.
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Abstract: The present paper briefly considers the effect of a new antitumor antibiotic, bleomycin1), on several strains of transplantable mouse ascites tumors, all of which were originally established as syngeneic in tumor-host relationship. The antibiotic showed moderate to marked effects upon Rous sarcoma virusinduced mouse ascites sarcoma at fairly wide dose level, particularly when F1 hybrid mice were employed as host animals. It gave, however, almost no effect upon virus-producing Friend ascites tumor and mouse ascites plasmacytoma.
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Bleomycin, an antibiotic that removes thymine from double-stranded DNA.
TL;DR: This chapter reviews that bleomycins are members of a new class of DNA-modifying agents, the quasi-enzymes, and that antitumor activity of bleomycin is dependent upon uptake, inactivation and activation, leading to tissue- and organ-specific actions.
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Strand-scission of HeLa cell deoxyribonucleic acid by bleomycin in vitro and in vivo.
Yoshisada Fujiwara,Teruo Kondo +1 more
TL;DR: The data suggest that BLM may either hardly enter HeLa S3 cells or may be readily inactivated, and the ability of bleomycin to cause strand breaks of DNA in vitro has been confirmed by means of alkaline sucrose sedimentation.
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Copper chelator enhancement of bleomycin cytotoxicity.
TL;DR: The notion that reducing Cu2+ levels and/or increasing O2‐ concentrations can modify the cytotoxicity of bleomycin is supported.
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Preclinical toxicologic evaluation of bleomycin (NSC 125 066), a new antitumor antibiotic.
George R. Thompson,John R. Baker,Fleischman Rw,Harris Rosenkrantz,Ulrich Schaeppi,Cooney Da,Ruth D. Davis +6 more
TL;DR: Bleomycin, a potent antitumor antibiotic obtained from Streptomyces verticillus, was administered to 14 dogs at doses from 0.312 to 5.0 mg/kg iv every 4 days for 6 to 28 wk, indicating that bleomycin may have affected cellular sulfhydryl or disulfide groups or availability of essential metals in those organs that concentrated the compound.
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References
Abnormal serum protein and bone destruction in transmissible mouse plasma cell neoplasm (multiple myeloma).
TL;DR: A plasma cell neoplasm X5563 of the C3H mouse has been described, which resembles human multiple myeloma by similar histologic appearance of the neoplastic plasma cell and production of an abnormal serum globulin.
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Studies on allogeneic inhibition I. Differential behavior of mouse tumors transplanted to homozygous and F1 hybrid hosts
TL;DR: Lymphomas, carcinomas and sarcomas originating in homozygous hosts grew better when transplanted into syngeneic mice than in F1 hybrids between the syngenesic and an allogeneic strain.
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An ascites tumor derived from early splenic lesion of friend's disease
Yoji Ikawa,Haruo Sugano +1 more
TL;DR: The authors succeeded in realizing some characters of the proliferating cells in Friend's disease by analyzing the spleen foci in early stages, and it was still questionable whether the minute spleenfoci consisting of erythrogenic tumor cells would really be continuous with the final tumorous proliferation.
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