Effect of Musa acuminata Starch concentration on the Disintegrant Activity of Paracetamol Tablets
TL;DR: In this article , the effect of Musa acuminata starch concentration on the disintegrant activity of paracetamol tablets was investigated on unripe banana fruits extracted with distilled water and 0.05M sodium hydroxide.
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Abstract: Today, tablets are one of the most widely used pharmaceutical dosage forms. Both active pharmaceutical ingredients (API) and inactive ingredients such as disintegrants are found in pharmaceutical dosage forms. Disintegrants are essential for dissolving the tablet into small particles and increasing the surface area of the API when it is exposed to gastrointestinal fluids. As a result, choosing the right type and concentration of disintegrant is often the most important aspect in determining tablet quality. Effect of Musa acuminata starch concentration on the disintegrant activity of paracetamol tablets was now researched on. Starch from unripe banana fruits was extracted with distilled water and 0.05M sodium hydroxide. Banana starch powder at concentrations of 5, 10 and 15% w/w were used to formulate paracetamol tablets by direct compression. Starch powder and tablet properties were evaluated. Increase in concentration of banana starch powder from 5-15% w/w led to a decrease in disintegration time, weight variation, and an increase in friability. The tablets formulated from banana starch at all concentration were comparable to tablet properties in the standard BP 2009. The starch powder pH, true density, bulk density, tapped density, angle of repose, Hausner’s ratio and Carr’s index were 6.57, 1.51g/ ml, 0.55g/ml, 0.61g/ml, 32.3o , 1.11 and 9.90, respectively. The tablets exhibited disintegration time, weight variation, thickness, and friability values ranging from 0.55-0.44min, 1.66-0.59%, 4-3.39mm, 0.13- 0.55%, respectively. The tablets met acceptable Pharmacopoeia requirements at starch concentration studied. Results revealed that banana starch could be used as a disintegrant in paracetamol tablet formulation due its comparable properties with the standard BP 2009 specifications. Musa acuminata starch when used at concentration of 15% gives optimum disintegrant activity. Keywords: Musa acuminate, Starch concentration, Disintegrant, Paracetamol tablets
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Citations
Comparative Evaluation of Sweet Potato and Peas Starches as Disintegrants in the Foundation of Paracetamol Tablets
S. Immaculate
TL;DR: Sweet potato and pea starches have good disintegrant properties and can be used as an alternative to corn starch in the formulation of paracetamol tablets.
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TL;DR: This review further summarises mathematical models used to simulate disintegration phenomena and to predict drug release kinetics and methods used to study the disintegration in-situ.
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