Effect of Hydrocortisone Aceponate - Gentamicin - Miconazole Topical Otic Combination for Treating Canine Otitis Externa

TL;DR: Easotic treatment once daily for 5 days and 10 days appears to be effective and safe treatment for canine otitis externa.

Abstract: Fifty-four dogs with otitis externa were enrolled in the study for the Evaluation of efficacy of a Hydrocortisone aceponate - Gentamicin - Miconazole otic combination (Easotic ® , Virbac, Carros, France). Otitis externa patients were treated by Easotic ® once daily for 5 days and 2 days off treatment and evaluated on 7 th day. If otitis externa persisted, additional Easotic ® treatment was administered once daily for 5 days and rested 2 days and reevaluated on 14 th day. For the evaluation of efficacy of Easotic ® , eight clinical signs were scored on a severity scale and infectious agents from ear sample were also graded using semi-quantitative scale at each visit. Sum of clinical scores and cytological scores was defined as Global Clinical Score. When Easotic ® was applied once daily for 5 days, global clinical score was reduced 76.0%. When Easotic ® was administered for 10 days, during first 5 days administration, 46.6% reduction of global clinical score was detected. During additional 5 days administration, 82.2% reduction of global clinical score was observed compared with Day 0. Any relevant adverse effect was not reported during the study in all cases. Thus, Easotic ® treatment once daily for 5 days and 10 days appears to be effective and safe treatment for canine otitis externa.