Effect of diets with different calcium and phosphorus contents on the skeletal development and blood chemistry of growing great danes
I. Schoenmakers,Herman A.W. Hazewinkel,George Voorhout,Cathy S. Carlson,Daniel C. Richardson +4 more
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TL;DR: The skeletal development of three groups of great dane dogs, fed a diet composed according to the published nutritional requirements for dogs (controls) or with increased calcium or calcium and phosphorus content, was examined radiographically, histologically and biochemically.
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Abstract: The skeletal development of three groups of great dane dogs, fed a diet composed according to the published nutritional requirements for dogs (controls) or with increased calcium or calcium and phosphorus content, was examined radiographically, histologically and biochemically. The diets were fed from the time the dogs first began eating food in addition to their dam's milk, until they were 17 weeks old. Thereafter, the calcium and phosphorus intakes of the dogs in the high calcium groups were normalised for a further 10 weeks. The dogs fed the high calcium diet without a proportionally high phosphorus intake became hypercalcaemic and hypophosphataemic, and had severe disturbances in skeletal development, growth, and mineralisation which were typical for rickets. After their calcium intake was normalised the lesions of rickets resolved but osteochondrotic lesions became apparent. The dogs fed the high calcium and phosphorus diet became slightly hypophosphataemic, their growth was retarded, and they had disturbances in skeletal development resembling osteochondrosis, which had only partly resolved after 10 weeks on the normal calcium and phosphorus diet.
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References
Calcium metabolism in Great Dane dogs fed diets with various calcium and phosphorus levels.
Herman A.W. Hazewinkel,Walter E. van den Brom,Arie Th. Van 'T Klooster,George Voorhout,Ank M.T.C. van Wees +4 more
TL;DR: The influence of dietary calcium on calcium metabolism was investigated in growing dogs that reach an adult body weight similar to that of humans, and the mean plasma calcium concentrations did not differ between groups during the studies, whereas that of inorganic phosphorus revealed temporal aberrations in two groups.
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TL;DR: Biochemical assays have opened a new era where changes in bone metabolism can be detected in hours to days, and should be especially helpful to the development of new drugs and the optimization of the use of approved drugs.
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TL;DR: This investigation concluded that the primary lesion occurring in osteochondrosis of dogs from the large and giant breeds is an acquired pattern of osteopenic and biomechanically weak subchondral spongiosa that cannot provide adequate bony support for the articular cartilage of joints.
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Diagnosis of copper deficiency in cattle
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Morphological findings in young dogs chronically fed a diet containing excess calcium.
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