[Effect of a new antiviral compound 1-morpholinomethyltetrahydro-2(1H)-pyrimidinone on the interaction of influenza virus proteins with flat lipid membranes].

TL;DR: The antiviral preparation 1-morpholinomethyltetrahydro-2(1H)-pyrimidinone (abbreviation DD-13) inhibiting reproduction of certain enveloped viruses belonging to groups of orthomyxoviruses and alphaviruses, influenza type A viruses among them, inhibited adsorption and insertion of influenza virus M protein into model bilayer lipid membranes.

Abstract: The antiviral preparation 1-morpholinomethyltetrahydro-2(1H)-pyrimidinone (abbreviation DD-13) inhibiting reproduction of certain enveloped viruses belonging to groups of orthomyxoviruses and alphaviruses, influenza type A viruses among them, inhibited adsorption and insertion of influenza virus M protein into model bilayer lipid membranes. The preparation did not interact directly with lipid bilayers but, after pretreatment of M protein with it, inhibited M protein interaction with the membranes: adsorption and insertion into the bilayer DD-13 did not affect the interaction of influenza virus surface glycoproteins with the model lipid membranes. It is concluded that the DD-13 preparation, not interacting with the membranes directly, in native systems may modify the protein-lipid interactions at the stages of virus penetration into the cell, penetration of M protein-coated nucleocapsid into the cell nucleus through the nuclear membrane, as well as at the stage of virus particle assembly on the plasma membrane of the infected cell.