Journal Article10.1016/S0161-6420(99)90497-9
Early Manifest Glaucoma Trial: design and baseline data.
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TL;DR: The EMGT is the first large randomized, clinical trial to evaluate the role of immediate pressure reduction, as compared to no initial reduction, in patients with early glaucoma and normal or moderately elevated IOP, and its results will have implications for the clinical management of glau coma.
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About: This article is published in Ophthalmology. The article was published on 01 Nov 1999. The article focuses on the topics: Intraocular pressure & Glaucoma.
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Citations
A Comparison of Visual Field Progression Criteria of 3 Major Glaucoma Trials in Early Manifest Glaucoma Trial Patients.
Anders Heijl,Boel Bengtsson,Balwantray C. Chauhan,Marc F. Lieberman,Ian Cunliffe,Leslie Hyman,M. Cristina Leske +6 more
TL;DR: The EMGT criteria identified progression earlier and more often than AGIS and CIGTS criteria and sustainability increased with time after progression; it averaged 79%, 84%, and 81%, respectively, for AGIS, CIGts, and EMGT criterion during the first year after the first progression and 95%, 100%, and 93% during the fourth year after progression.
Investigating the clinical usefulness of definitions of progression with 10-2 visual field.
Shotaro Asano,Hiroshi Murata,Yuri Fujino,Takehiro Yamashita,Atsuya Miki,Yoko Ikeda,Kazuhiko Mori,Masaki Tanito,Ryo Asaoka +8 more
TL;DR: In this paper, the authors investigate the clinical validity of the Guided Progression Analysis definition (GPAD) and cluster-based definition (CBD) with the Humphrey Field Analyzer 10-2 test in diagnosing glaucomatous visual field (VF) progression, and to introduce a novel definition with optimised specificity by combining the "any-location" and "cluster-based" approaches (hybrid definition).
Risk factors for primary open-angle glaucoma – A brief review
A. M. Stephen,Jayasri Periyandavan,Subashini Kaliaperumal +2 more
TL;DR: This review identifies various ocular and systemic risk factors for primary open-angle glaucoma, emphasizing the importance of risk assessment and opportunistic screening to improve diagnosis and reduce disease burden, particularly in developing countries.
Additional file 1 of Effect of medically lowering intraocular pressure in glaucoma suspects with high myopia (GSHM study): study protocol for a randomized controlled trial
Lin Feng-bin,Wang Wei,Jin Ling,Liu-Bing Qian,Liu, Yu-Hong,CHEN Mei-Ling,Gao Kai,Friedman, David S.,Jonas, Jost B.,Aung, Tin,Lv Lin,Liu Yi-zhi,Zhang Xiu-lan +12 more
- 30 Sep 2020
Abstract: Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents.
References
Longitudinal data analysis using generalized linear models
Kung Yee Liang,Scott L. Zeger +1 more
TL;DR: In this article, an extension of generalized linear models to the analysis of longitudinal data is proposed, which gives consistent estimates of the regression parameters and of their variance under mild assumptions about the time dependence.
Proportional hazards tests and diagnostics based on weighted residuals
TL;DR: In this article, Chen et al. showed that a treatment effect that decreases with time can be directly visualized by smoothing an appropriate residual plot, which can be expressed as a weighted least-squares line fitted to the residual plot.
5.4K
Models for longitudinal data: a generalized estimating equation approach.
TL;DR: This article discusses extensions of generalized linear models for the analysis of longitudinal data in which heterogeneity in regression parameters is explicitly modelled and uses a generalized estimating equation approach to fit both classes of models for discrete and continuous outcomes.
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2K