Journal Article10.1177/1352458506071196
Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis
L. Feuillet,Françoise Reuter,Bertrand Audoin,Irina Malikova,K. Barrau,A. Ali Cherif,Jean Pelletier +6 more
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TL;DR: Patients with CISSMS had a significant, frequent, and circumscribed cognitive impairment, focused on memory, speed of information processing, attention and executive functions.
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Abstract: Cognitive impairment in patients with multiple sclerosis (MS) is a common occurrence and is generally fairly circumscribed. The prevalence of the cognitive deficits usually encountered could vary with the clinical course of the disease. To investigate whether the presence of cognitive impairment may occur in the very early stage of MS, we assessed the cognitive status of a group of 40 patients presenting with a recently diagnosed clinically isolated syndrome suggestive of MS (CISSMS), in comparison with 30 age-, sex-, and educational level-matched healthy control subjects. An extensive battery of neuropsychological tests was used to explore verbal and non-verbal memory, attention, concentration, speed of information processing, language and abstract reasoning. Patients with CISSMS had a significant, frequent (57%), and circumscribed cognitive impairment, focused on memory, speed of information processing, attention and executive functions.
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Citations
Reports of patients and relatives from the CogniCIS study about cognition in clinically isolated syndrome: what are our patients telling us?
TL;DR: In CIS, patient and relative MSNQ scores are influenced by psychosocial variables rather than actual objective cognitive status, and formal cognitive test assessment is recommended for CIS patients.
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•Journal Article
Implications for Multiple Sclerosis in the Era of the Affordable Care Act: An Evolving Treatment Paradigm
Luigi Brunetti,Samuel F Hunter +1 more
TL;DR: A review of the available pharmacotherapeutic options for treating MS is provided, the impact of adherence to therapy is discussed, and the importance of managing comorbidities often experienced by patients with MS is described.
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Cognitive phenotypes in multiple sclerosis: mapping the spectrum of impairment.
Damiano Mistri,Nicolò Tedone,Diana Biondi,Carmen Vizzino,Elisabetta Pagani,Maria A. Rocca,Massimo Filippi +6 more
TL;DR: Five cognitive phenotypes emerged, characterized by distinct demographic, clinical and MRI features, indicating potential variations in the neural substrates of dysfunction throughout disease stages.
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Evaluating response to disease-modifying therapy in relapsing multiple sclerosis
Mark S. Freedman,Mohammad Abdoli +1 more
TL;DR: Despite the broadening range of available treatments, the response of multiple sclerosis patients to disease-modifying therapies remains quite heterogeneous, thus a scheme is required in order to flag individuals achieving a suboptimal treatment response, so that they may switch to a different, possibly more effective disease- modifying therapy.
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Neurochemical Changes in the Brain and Neuropsychiatric Symptoms in Clinically Isolated Syndrome
TL;DR: It is suggested that neurochemical changes in the NAWM assessed with single-voxel 1H-MRS are associated with cognitive performance and affective symptoms in patients with CIS.
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References
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
TL;DR: The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.
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Cognitive impairment in early-onset multiple sclerosis. Pattern, predictors, and impact on everyday life in a 4-year follow-up.
Maria Pia Amato,G. Ponziani,Giovanni Pracucci,Laura Bracco,Gianfranco Siracusa,Luigi Amaducci +5 more
TL;DR: Cognitive dysfunction proves to be a predictor of handicap in everyday life, even in patients in the incipient phase of multiple sclerosis.
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Cognitive impairment in probable multiple sclerosis.
Anat Achiron,Yoram Barak +1 more
TL;DR: Prevalent cognitive impairment already exists at onset of multiple sclerosis, and verbal abilities and attention span were most frequently affected.
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Clinically isolated lesions of the type seen in multiple sclerosis: a cognitive, psychiatric, and MRI follow up study.
TL;DR: A 4 1/2 year follow up study documenting magnetic resonance imaging, psychometric, and psychiatric abnormalities was undertaken in a group of 48 patients with clinically isolated lesions--for example, optic neuritis--which are frequently the harbinger of MS.
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Working memory impairment in early multiple sclerosis. Evidence from an event-related potential study of patients with clinically isolated myelopathy.
TL;DR: Objective evidence of subclinical working memory dysfunction in patients at an early stage of demyelinating disease is provided, i.e. when they first present with clinically isolated spinal cord lesions and before they have developed symptoms of cognitive or memory dysfunction.
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