Journal Article10.1177/1352458506071196
Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis
L. Feuillet,Françoise Reuter,Bertrand Audoin,Irina Malikova,K. Barrau,A. Ali Cherif,Jean Pelletier +6 more
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TL;DR: Patients with CISSMS had a significant, frequent, and circumscribed cognitive impairment, focused on memory, speed of information processing, attention and executive functions.
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Abstract: Cognitive impairment in patients with multiple sclerosis (MS) is a common occurrence and is generally fairly circumscribed. The prevalence of the cognitive deficits usually encountered could vary with the clinical course of the disease. To investigate whether the presence of cognitive impairment may occur in the very early stage of MS, we assessed the cognitive status of a group of 40 patients presenting with a recently diagnosed clinically isolated syndrome suggestive of MS (CISSMS), in comparison with 30 age-, sex-, and educational level-matched healthy control subjects. An extensive battery of neuropsychological tests was used to explore verbal and non-verbal memory, attention, concentration, speed of information processing, language and abstract reasoning. Patients with CISSMS had a significant, frequent (57%), and circumscribed cognitive impairment, focused on memory, speed of information processing, attention and executive functions.
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Neurocognitive performance in relapsing-remitting multiple sclerosis patients is associated with metabolic abnormalities of the thalamus but not the hippocampus- GABA-edited 1H MRS study.
Ema Kantorová,Petra Hnilicová,Wolfgang Bogner,Marian Grendar,Ján Grossmann,Slavomíra Kováčová,Eva Heckova,Bernhard Strasser,Daniel Čierny,Kamil Zeleňák,Egon Kurča +10 more
TL;DR: In this paper, the authors investigated how the neuropsychological status depends on the thalamus and hippocampus's metabolic processes, using γ-aminobutyric acid-edited magnetic resonance spectroscopy (GABA-edited 1H MRS) in patients with early MS.
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TL;DR: Neurobehavioral abnormalities afflict up to 90% of patients with MS and cause a greater burden of disability than motor ones, according to a study published in JAMA Oncology.
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Cognitive impairment in patients with clinically isolated syndrome
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TL;DR: Cognitive abnormalities have been extensively studied in Multiple Sclerosis, but little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS).
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What is the relevance of quality of life assessment for patients with attention impairment
Karine Baumstarck,Mohamed Boucekine,Irina Klemina,Françoise Reuter,Valérie Aghababian,Anderson Loundou,Jean Pelletier,Pascal Auquier +7 more
TL;DR: This study suggests that attention impairment dysfunction did not compromise the reliability and validity of the self-reported QoL questionnaires and the internal/external validity indices were close to those of the reference population.
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Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
TL;DR: The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.
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Cognitive impairment in early-onset multiple sclerosis. Pattern, predictors, and impact on everyday life in a 4-year follow-up.
Maria Pia Amato,G. Ponziani,Giovanni Pracucci,Laura Bracco,Gianfranco Siracusa,Luigi Amaducci +5 more
TL;DR: Cognitive dysfunction proves to be a predictor of handicap in everyday life, even in patients in the incipient phase of multiple sclerosis.
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Cognitive impairment in probable multiple sclerosis.
Anat Achiron,Yoram Barak +1 more
TL;DR: Prevalent cognitive impairment already exists at onset of multiple sclerosis, and verbal abilities and attention span were most frequently affected.
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Clinically isolated lesions of the type seen in multiple sclerosis: a cognitive, psychiatric, and MRI follow up study.
TL;DR: A 4 1/2 year follow up study documenting magnetic resonance imaging, psychometric, and psychiatric abnormalities was undertaken in a group of 48 patients with clinically isolated lesions--for example, optic neuritis--which are frequently the harbinger of MS.
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Working memory impairment in early multiple sclerosis. Evidence from an event-related potential study of patients with clinically isolated myelopathy.
TL;DR: Objective evidence of subclinical working memory dysfunction in patients at an early stage of demyelinating disease is provided, i.e. when they first present with clinically isolated spinal cord lesions and before they have developed symptoms of cognitive or memory dysfunction.
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