Journal Article10.1016/0165-3806(89)90021-7
Early axonal differentiation in mouse CNS delineated by an antibody recognizing extracted neurofilaments.
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TL;DR: The concept that the leading process of some classes of migratory neurons becomes transformed into an axon is supported by the expression of C2 immunoreactivity in radially ascending processes from principle neuron classes in the fetal retina and cerebellum.
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About: This article is published in Developmental Brain Research. The article was published on 01 Oct 1989. The article focuses on the topics: Neurofilament & Neuron.
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Citations
Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries
A. Bulfone,Luis Puelles,Matthew H. Porteus,Michael A. Frohman,Gail R. Martin,John L.R. Rubenstein +5 more
TL;DR: A model for forebrain segmentation is suggested based on patterns of expression found within the dorsal thalamus for the Gbx- 2 and Wnt-3 genes, consistent with neuromeric theories of forebrain development.
606
Expression of neuron-specific tubulin defines a novel population in the proliferative layers of the developing telencephalon
J. R. L. Menezes,Marla B. Luskin +1 more
TL;DR: The results suggest that TuJ1 immunoreactivity distinguishes two neuronal populations: those that remain for an indefinite period of time in the proliferative zones, and those that leave the proliferation zones soon after being generated.
498
Distribution of TAG-1/axonin-1 in fibre tracts and migratory streams of the developing mouse nervous system.
TL;DR: The axonal cell adhesion molecule, TAG‐1/axonin‐1, stimulates axonal growth and supports neurite fasciculation in vitro and is mapped throughout the developing nervous system of the mouse.
144
Guidance of Circumferentially Growing Axons by Netrin-Dependent and -Independent Floor Plate Chemotropism in the Vertebrate Brain
TL;DR: Results suggest that netrin-1 functions as a global guidance cue for attraction to the midline, and floor plate-mediated chemorepulsion may also operate generally to direct dorsal migrations, but its molecular basis may involve bothNetrin-dependent and -independent mechanisms.
129
Expression of HB-GAM (heparin-binding growth-associated molecules) in the pathways of developing axonal processes in vivo and neurite outgrowth in vitro induced by HB-GAM.
Heikki Rauvala,Anu Vanhala,Eero Castre´n,Riitta Nolo,Erkki Raulo,Jussi Merenmies,Pertti Panula +6 more
TL;DR: It is suggested that in developing nervous tissues HB-GAM is deposited to an extracellular location in developing axon pathways and it interacts with heparin-like molecules of the neuron surface to promote formation of neural connections.
101
References
The embryonic development of the cerebellum in normal and reeler mutant mice
TL;DR: It is suggested that, in normal cerebellar development, a specific, genetically determined mechanism is responsible for the organization and the stabilization of postmigratory neurons and that this mechanism is affected by the reeler mutation.
142
Developmental changes in unique cell surface antigens of chick embryo spinal motoneurons and ganglion cells.
Hideaki Tanaka,Kunihiko Obata +1 more
TL;DR: Four monoclonal antibodies that bound to cell surface antigens that revealed heterogeneities in cell surface neuronal molecules and their transient and sequential appearance during embryonic development are reported here.
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Posttranslational modification of neurofilament proteins by phosphate during axoplasmic transport in retinal ganglion cell neurons.
TL;DR: Observations that a considerable proportion of phosphate groups initially added to L and M were later removed as neurofilaments advanced along RGC axons support the notion that the changing phosphorylation state of NFP subunits during axoplasmic transport reflects a dynamic equilibrium between phosphorylated and dephosphorylation events.
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Novel monoclonal antibodies provide evidence for the in situ existence of a nonphosphorylated form of the largest neurofilament subunit.
TL;DR: Evidence is provided for the in situ existence of NF200 epitopes that are not phosphorylated in some classes of neurons or regions of a neuron, but are modified by phosphorylation in other neurons or neuronal domains.
119
Asynchrony in the expression of guanosine 3′:5′-phosphate-dependent protein kinase by clusters of purkinje cells during the perinatal development of rat cerebellum
Marion Wassef,Constantino Sotelo +1 more
TL;DR: It is concluded that a compartmentalization of the cerebellar cortex is present very early and is evidenced by differences in the biochemical maturation of Purkinje cells.
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