Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron seqFISH

doi:10.1016/J.CELL.2018.05.035

Open AccessJournal Article10.1016/J.CELL.2018.05.035

Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron seqFISH

Sheel Shah, +11 more

- 12 Jul 2018

- Cell

- Vol. 174, Iss: 2, pp 363-376

318

TL;DR: Surprisingly, the global nascent transcription oscillated asynchronously in individual cells with a period of 2 hr in mouse embryonic stem cells, as well as in fibroblasts, and reveals nuclear organizational principles and fast dynamics in single cells that are otherwise obscured.

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