Dynamic Structural Differences between Human and Mouse STING Lead to Differing Sensitivity to DMXAA

TL;DR: STING agonists are being developed as a novel cancer therapeutic, and a greater understanding of STING pathway regulation is leading to a broadened list of candidate immune regulatory targets.

TL;DR: The STING pathway is also increasingly understood to have other anti-tumor functions such as modulation of the vasculature and augmentation of adaptive immunity via the support of tertiary lymphoid structure development.

TL;DR: In this paper , the authors summarized the synergistic antitumor efficacies and mechanisms of α-PD-1/PD-L1 in combination with other therapies, and focused on the advances of αPD- 1/PD L 1-based immunomodulatory strategies in clinical studies.

TL;DR: The body of evidence supporting a synergistic role of STING agonists with currently approved ICI therapies is summarized and whether, despite the numerous obstacles encountered to date, the clinical development of STing agonist as novel anti-cancer therapeutics may still hold the promise of broadening the reach of cancer immunotherapy is discussed.

TL;DR: Together, these backbone and side chain modifications (hereafter called ff14SB) not only better reproduced their benchmarks, but also improved secondary structure content in small peptides and reproduction of NMR χ1 scalar coupling measurements for proteins in solution.

TL;DR: PTRAJ and its successor CPPTRAJ are described, two complementary, portable, and freely available computer programs for the analysis and processing of time series of three-dimensional atomic positions and the data therein derived.

TL;DR: The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.

TL;DR: This corrects the article to show that the H2O2/H2O/O2 mixture is dominated by the H3O/ O2 mixture, rather than the O2/O3 mixture, which is more commonly associated with H2Os.