Patent
Dual variable domain immunoglobulins and uses thereof
Chengbin Wu,Tariq Ghayur,Richard W. Dixon,Jochen G. Salfeld +3 more
- 18 Aug 2006
900
TL;DR: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
read more
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Citations
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TL;DR: In this article, the present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use, and their use relates to the use of domain exchange.
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TL;DR: In this paper, the diabody molecules of the present invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on different or differing antigens.
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Antibody molecules to pd-1 and uses thereof
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TL;DR: In this article, the anti-PD-1 antibody molecules can be used to treat, prevent and diagnose cancerous or infectious conditions and disorders, and they can be found to specifically bind to PD-1.
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David W. Borhani,Wolfgang Fraunhofer,Hans-Juergen Krause,Anette Koenigsdorfer,Gerhard Winter,Stefan Gottschalk +5 more
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TL;DR: In this article, a batch crystallization method for crystallizing an anti-hTNFα antibody which allows the production of said antibody on an industrial scale was presented; antibody crystals as obtained according to said method; compositions containing said crystals as well as methods of use of said crystals and compositions.
133
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Antibodies directed to her-3 and uses thereof
Mike Rothe,Martin Treder,Susanne Hartmann,Daniel J. Freeman,Radinsky Bob,Eric Borges +5 more
- 29 Dec 2006
TL;DR: In this article, a method for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin is presented. But the method is restricted to polynucleotides encoding the same.
133
New drugs for asthma, allergy and COPD
Trevor T. Hansel,Peter J. Barnes +1 more
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TL;DR: The need for new therapyCurrent therapy for asthma current therapy for COPD pharmacogenetics delivery of biologics to the lung immunopathology - comparison of COPD and asthma monitoring lung function airway hyperresponsiveness airways remodelling exhaled breath analysis clinical studies on new drugs.
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Non-affinity purification of proteins
Fahner Robert Lee,Deborah Follman,Benedicte Lebreton,Robert van Reis +3 more
- 25 Apr 2003
TL;DR: In this paper, a method for protein purification that involves the combination of non-affinity chromatography with HPTFF was presented, which is a modification of the method described in this paper.
132
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Antibodies to human il-1beta
Hermann Gram,Di Padova Franco E +1 more
- 20 Aug 2001
TL;DR: In this article, the CDRs of the heavy and light chains having amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteoporosis and other inflammatory arthritides.
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