Dual variable domain immunoglobulins and uses thereof

TL;DR: In this paper, the authors provide compositions and methods for treating diseases associated with expression of CD19, including methods of administering a genetically modified T cell expressing a chimeric antigen receptor (CAR) that comprises a CD19 binding domain.

TL;DR: In this paper, the diabody molecules of the present invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on different or differing antigens.

TL;DR: In this article, the anti-PD-1 antibody molecules can be used to treat, prevent and diagnose cancerous or infectious conditions and disorders, and they can be found to specifically bind to PD-1.

TL;DR: It is demonstrated that intraarticular injection of IL-1 into rabbit knee joints induces the accumulation of polymorphonuclear and mononuclear leukocytes in the joint space and the loss of proteoglycan from the articular cartilage, supporting the hypothesis that IL- 1 acts directly to mediate the erosive processes of chronic arthritis.

TL;DR: Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided in this paper, where the particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 µm and 30 µm.

TL;DR: In the crystal lattice, CTLA-4 and B7-1 pack in a strikingly periodic arrangement in which bivalent CTLA -4 homodimers bridge bivalent B 7-1 homodIMers, underscoring the importance of potent inhibitory signalling in human immune responses.

TL;DR: It is concluded from this pilot study that insulin treatment with an implanted, variable-rate, programmable pump is feasible for periods up to two years.