Patent
Dual variable domain immunoglobulins and uses thereof
Chengbin Wu,Tariq Ghayur,Richard W. Dixon,Jochen G. Salfeld +3 more
- 18 Aug 2006
900
TL;DR: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
read more
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Citations
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Bivalent, bispecific antibodies
Christian Klein,Wolfgang Schaefer +1 more
- 16 Dec 2008
TL;DR: In this article, the present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use, and their use relates to the use of domain exchange.
354
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Treatment of cancer using humanized anti-cd19 chimeric antigen receptor
Jennifer Brogdon,Carl H. June,Andreas Loew,Marcela V. Maus,John Scholler +4 more
- 15 Mar 2014
TL;DR: In this paper, the authors provide compositions and methods for treating diseases associated with expression of CD19, including methods of administering a genetically modified T cell expressing a chimeric antigen receptor (CAR) that comprises a CD19 binding domain.
331
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Covalent Diabodies and Uses Thereof
Leslie S. Johnson,Ling Huang +1 more
- 17 Apr 2006
TL;DR: In this paper, the diabody molecules of the present invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on different or differing antigens.
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Antibody molecules to pd-1 and uses thereof
Gordon J. Freeman,Arlene H. Sharpe,Walter A. Blattler,Jennifer Marie Mataraza,Catherine Anne Sabatos-Peyton,Chang Hwai Wen,Frey Gerhard Johann +6 more
- 23 Jan 2015
TL;DR: In this article, the anti-PD-1 antibody molecules can be used to treat, prevent and diagnose cancerous or infectious conditions and disorders, and they can be found to specifically bind to PD-1.
271
References
Patent
Bispecific anti-cd28 antibody molecule
Gundram Jung
- 09 Nov 2002
TL;DR: In this article, a bispecific antibody molecule is defined as one with at least one binding site with a variable domain on a light chain (VL) and another on a heavy chain (VH).
19
Patent
Anti-alpha2 integrin antibodies and their uses
Elias Lazarides,Woods Catherine,Mark A. Bernard +2 more
- 17 Nov 2006
TL;DR: In this paper, humanized anti-α2 integrin antibodies have been used to inhibit the interaction of α2β1 integrin with collagen and to treat α2α1-mediated disorders.
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