Journal Article10.1021/ACSAMI.6B02403
Dual Stimuli-Responsive Hybrid Polymeric Nanoparticles Self-Assembled from POSS-Based Starlike Copolymer-Drug Conjugates for Efficient Intracellular Delivery of Hydrophobic Drugs
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TL;DR: The hybrid POSS-based polymeric nanoparticles offer an efficient approach to transport hydrophobic drugs for cancer therapy and lead to enhanced cytotoxicity against PC-3 human prostate carcinoma cells.
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Abstract: To further fine tune drug release and enhance therapeutic effects of polyhedral oligomericsilsesquioxane (POSS)-based nanomedicine, a starlike organic–inorganic conjugate was synthesized by grafting semitelechelic N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers to a POSS rigid core through reductively degradable disulfide bonds. The hydrophobic docetaxel (DTX) was attached to the grafts by pH-sensitive hydrazone bonds and also encapsulated into the POSS core (SP-DTX). Thus, the final amphiphilic star-shaped conjugates could self-assemble into nanoparticles and exhibited conspicuous drug-loading capacity (20.1 wt %) based on the covalently conjugated accompanied by physically encapsulated DTX. The stimuli-responsive DTX release under acidic lysosomal and reducing cytoplasmic environments was verified, leading to enhanced cytotoxicity against PC-3 human prostate carcinoma cells. To evaluate the in vivo therapeutic effects of the DTX-loaded nanovehicles objectively, a stroma-rich, prostate xenograft tum...
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Citations
Fabrication of pH/Reduction Sensitive Polyethylene Glycol-Based Micelles for Enhanced Intracellular Drug Release.
TL;DR: In this paper, pH/reduction sensitive polymers (PCT) containing disulfide bonds and orthoester groups were synthesized to self-assemble in water and entrap doxorubicin to form drugloaded micelles (DOX/PCT).
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pH-triggered "PEG" sheddable and Folic acid-targeted nanoparticles for docetaxel delivery in breast cancer treatment.
Fangqian Sui,Zengjun Fang,Lingjun Li,Xinhuan Wan,Yongqing Zhang,Xiao Qing Cai +5 more
TL;DR: FPDPCNPs/DTX as a multifunctional nano-drug delivery system provides a promising strategy for efficiently delivering antitumour drugs.
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Block HPMA-based pH-sensitive gemcitabine pro-drug nanoaggregates for cancer treatment
TL;DR: A pH-sensitive, methoxy(polyethylene glycol)(hydrazone)block(hydroxypropyl methacrylamide), covalently linked to gemcitabine (mP(Hz)-bH(GEM)), was developed, which formed spherical nanoaggregates in the aqueous environment as discussed by the authors .
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Current State-of-the-Art and New Trends in Self-Assembled Nanocarriers as Drug Delivery Systems
TL;DR: The discussion about various delivery systems included the investigation conducted at the preliminary stage, i.e., preclinical trials and assessment of safety, and the innovative attempts with regard to prolonging drug action, improving bioavailability, avoiding drug resistance, enhancing cellular uptake, and so on have been discussed.
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Low temperature ATRP of POSS‐MA and its amphiphilic pentablock copolymers
TL;DR: In this article , a low temperature ATRP of methacryloisobutyl POSS (POSS-MA) was carried out, using poly(propylene glycol) (PPG)-based macroinitiator, in toluene with CuCl/PMDETA as the catalyst system, generating well-defined P(Poss-MA)-b-PPG-b-p(POSS)-MA) triblock copolymer with Ð ~ 1.1.
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