Journal Article10.1039/C4CE00211C
Drug solid solutions – a method for tuning phase transformations
Amit Delori,Pauline Maclure,Rajni M. Bhardwaj,Andrea Johnston,Alastair J. Florence,Oliver B. Sutcliffe,Iain D. H. Oswald +6 more
TL;DR: In this paper, a methodology for the modification of phase transition temperatures using (±)-4′-methylmethcathinone solid solutions as an exemplar is described. But this method does not consider the effect of the halide ion on phase transition temperature.
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Abstract: This paper describes a methodology for the modification of phase transition temperatures using (±)-4′-methylmethcathinone solid solutions as an exemplar. This method serves to show that by varying the composition of the halide ion one can systematically alter the temperatures at which phase transitions can occur in order to evade the possibility of interconversion between polymorphs during processing or storage of materials.
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Citations
Co-crystallization and small molecule crystal form diversity: from pharmaceutical to materials applications
TL;DR: Co-crystallization is the supramolecular phenomenon of aggregation of two or more different chemical entities in a crystalline lattice through non-covalent interactions.
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Engineering crystal properties through solid solutions
TL;DR: In this article, a structural disorder is characterized by a variation of stoichiometry in continuum, and the variation corresponds to physicochemical properties, and offers an opportunity for the materials' fine-tuning.
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A rough guide to molecular solid solutions: design, synthesis and characterization of mixed crystals
TL;DR: In this article, practical principles for the design, synthesis and characterization of molecular solid solutions are summarized and discussed from a crystal engineering perspective, which can help in obtaining materials with improved and tunable properties.
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Micro‐/Nanostructured Multicomponent Molecular Materials: Design, Assembly, and Functionality
Dongpeng Yan,Dongpeng Yan +1 more
TL;DR: This review describes recent advances and current directions in the assembly and applications of crystalline multicomponent micro-/nanostructures and introduces the design strategies for multicomponents systems based on molecular recognition and crystal engineering principles.
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Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone
Gavin McLaughlin,Noreen Morris,Pierce V. Kavanagh,John D. Power,Geraldine Dowling,Brendan Twamley,John E. O'Brien,Brian Talbot,Donna Walther,John S. Partilla,Michael H. Baumann,Simon D. Brandt +11 more
TL;DR: The isomer N-methoxymephedrone was found to be a weak uptake blocker at DAT, NET and SERT, as well as a fully efficacious substrate-type releasing agent across all three transporters with EC50 values in the low micromolar range.
References
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