Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons.
Fiona Francis,Annette Koulakoff,Dominique Boucher,Philippe Chafey,Bruce T. Schaar,M C Vinet,Gaëlle Friocourt,Nathalie McDonnell,Orly Reiner,Axel Kahn,Susan K. McConnell,Yoheved Berwald-Netter,Philippe Denoulet,Jamel Chelly +13 more
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TL;DR: It is shown that Doublecortin is expressed in the brain throughout the period of corticogenesis in migrating and differentiating neurons, and Immunohistochemical studies show its localization in the soma and leading processes of tangentially migrating neuron, and a strong axonal labeling is observed in differentiating neuron.
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About: This article is published in Neuron. The article was published on 01 Jun 1999. and is currently open access. The article focuses on the topics: Doublecortin & Corticogenesis.
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Citations
Arctigenin Confers Neuroprotection Against Mechanical Trauma Injury in Human Neuroblastoma SH-SY5Y Cells by Regulating miRNA-16 and miRNA-199a Expression to Alleviate Inflammation.
Jie Song,Na Li,Yang Xia,Zhong Gao,Sa-feng Zou,Yuhui Yan,Shaoheng Li,Yue Wang,Ya-Kun Meng,Jingxian Yang,Tingguo Kang +10 more
TL;DR: Investigation of the capacity for arctigenin (ARC) to prevent secondary effects and the mechanism underlying the action of microRNA (miRNA)-199a and miRNA-16 in a mechanical trauma injury (MTI) model using SH-SY5Y cells in vitro provides insights into the pharmacological role of ARC in anti-inflammation and neuroprotection in neural cells.
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Metformin normalizes type 2 diabetes-induced decrease in cell proliferation and neuroblast differentiation in the rat dentate gyrus
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TL;DR: It is suggested that diabetes significantly reduces cell proliferation and neuroblast differentiation in the SZDG in diabetic rats and that metformin treatment normalizes the reduction of cell proliferation
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Analysis of adult neurogenesis: evidence for a prominent "non-neurogenic" DCX-protein pool in rodent brain.
Thomas Kremer,Ravi Jagasia,Annika Herrmann,Hugues Matile,Edilio Borroni,Fiona Francis,Hans-Georg Kuhn,Christian Czech +7 more
TL;DR: While Dcx protein level decline in adulthood and were detectable in neurogenic regions of the adult rodent brain, similar levels were also detectable in brain regions expected to bear no neurogenesis including the cerebral cortex and CA1/CA3 enriched hippocampus.
Sensitivity to the photoperiod and potential migratory features of neuroblasts in the adult sheep hypothalamus.
TL;DR: It is shown that new neuron production is also seasonally regulated since the density of DCX-positive cells changes according to the photoperiodic conditions at various time points of the year, and cyclin-dependant kinase-5 (Cdk5) and p35, two proteins involved in DCX phosphorylation and known to be critically involved in migration processes, are co-expressed in young hypothalamic neurons and are capable of in vivo interaction.
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STOP (stable-tubule-only-polypeptide) is preferentially associated with the stable domain of axonal microtubules.
Theresa Slaughter,Mark M. Black +1 more
TL;DR: Results are consistent with STOP dependent stabilization of axonal microtubules, with the difference between cold-stable polymer versus cold- + drug- stable polymer determined by the amount of STOP on the polymer.
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TL;DR: Electron microscopic analysis of serial sections showed that during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.
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doublecortin, a Brain-Specific Gene Mutated in Human X-Linked Lissencephaly and Double Cortex Syndrome, Encodes a Putative Signaling Protein
Joseph G. Gleeson,Joseph G. Gleeson,Kristina M. Allen,Jeremy W. Fox,Edward D Lamperti,Samuel F. Berkovic,Ingrid E. Scheffer,Edward C. Cooper,William B. Dobyns,Sharon R. Minnerath,M. Elizabeth Ross,Christopher A. Walsh +11 more
TL;DR: A novel 10 kb brain-specific cDNA interrupted by a balanced translocation in an XLIS patient that encodes a novel 40 kDa predicted protein named Doublecortin, which may define an Abl-dependent pathway regulating neuronal migration.
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Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats
Orly Reiner,Romeo Carrozzo,Ying Shen,Manfred Wehnert,Fabrizia Faustinella,William B. Dobyns,C. Thomas Caskey,David H. Ledbetter +7 more
TL;DR: The cloning of a gene (LIS-1, lissencephaly-1) in 17p13.3 that is deleted in Miller–Dieker patients is reported, identifying LIS-l as the disease gene and the deduced amino-acid sequence shows significant homology to β-subunits of heterotrimeric G proteins, suggesting that it could possibly be involved in a signal transduction pathway crucial for cerebral development.
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