Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons.
Fiona Francis,Annette Koulakoff,Dominique Boucher,Philippe Chafey,Bruce T. Schaar,M C Vinet,Gaëlle Friocourt,Nathalie McDonnell,Orly Reiner,Axel Kahn,Susan K. McConnell,Yoheved Berwald-Netter,Philippe Denoulet,Jamel Chelly +13 more
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TL;DR: It is shown that Doublecortin is expressed in the brain throughout the period of corticogenesis in migrating and differentiating neurons, and Immunohistochemical studies show its localization in the soma and leading processes of tangentially migrating neuron, and a strong axonal labeling is observed in differentiating neuron.
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About: This article is published in Neuron. The article was published on 01 Jun 1999. and is currently open access. The article focuses on the topics: Doublecortin & Corticogenesis.
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No effect of running and laboratory housing on adult hippocampal neurogenesis in wild caught long-tailed wood mouse
TL;DR: It is demonstrated that voluntary running and environmental changes which are effective in house mice and brown rats cannot influence AHN in long-tailed wood mice, indicating that in wild long-tails wood mice different regulatory mechanisms act on cell proliferation and neurogenesis.
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Developmental iodine deficiency and hypothyroidism impair neural development in rat hippocampus: involvement of doublecortin and NCAM-180.
Jian Gong,Wanyang Liu,Jing Dong,Yi Wang,Hongde Xu,Wei Wei,Jiapeng Zhong,Qi Xi,Qi Xi,Jie Chen +9 more
TL;DR: Developmental iodine deficiency and hypothyroidism impair the expression of doublecortin and NCAM-180, leading to nerve fiber malfunction and thus impairments in hippocampal development.
Changes in hippocampal neurogenesis throughout early development
TL;DR: Despite greatly reduced proliferative rates and recent reports of Nestin+ neuroprogenitor loss, total numbers of early Sox1+ NPCs were unaffected by age, and newborn cell survival within the dentate gyrus was increased, thus suggesting age-associated changes in fate-choice determination.
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Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5.
Mark E. Graham,Patricia Ruma-Haynes,Amanda Capes-Davis,Joanne M. Dunn,Timothy C. Tan,Valentina A. Valova,Phillip J. Robinson,Peter L. Jeffrey +7 more
TL;DR: Results do not support Ser-297 as the major cdk5 phosphorylation site in DCX, but indicate that DCX is subject to complex multisite phosphorylated sites.
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Identification and characterisation of the retinitis pigmentosa 1-like1 gene ( RP1L1 ): a novel candidate for retinal degenerations
Ivan Conte,Marta Lestingi,Anneke I. den Hollander,Giovanna Alfano,Carmela Ziviello,Mariarosaria Pugliese,Diego Circolo,Cristina Caccioppoli,Alfredo Ciccodicola,Sandro Banfi +9 more
TL;DR: The retina-specific expression and the sequence similarity to RP1 render RP1L1 a potential candidate for inherited retinal disorders, and a homologue in Fugu rubripes (pufferfish).
References
Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
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