Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons.

TL;DR: The human phenotypes suggests that there are at least four distinct and clinically-important steps in cortical neuronal migration, and the identification of the responsible genes suggests that multiple cellular processes are critical for correct neuronal positioning.

TL;DR: This work has implicated synergism between Reelin signaling and Cdk5 in contributing to the proper positioning of selective neuronal populations and provided a conceptual framework for exploring the molecular mechanisms underlying proper neuronal positioning in the developing mammalian brain.

TL;DR: The persistent expression of doublecortin by giant cells in the postnatal cerebrum is additional evidence of abnormal differentiation, which may be relevant to the pathogenesis of cortical disarray in TSC and FCD.

TL;DR: Surprisingly, 56 Fe irradiation improved performance on a dentate gyrus-reliant pattern separation task; irradiated mice learned faster and were more accurate than controls; these data urge revisitation of the broadly-held view that space radiation is detrimental to cognition.

TL;DR: The reeler phenotype seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin.

TL;DR: Electron microscopic analysis of serial sections showed that during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.

TL;DR: A novel 10 kb brain-specific cDNA interrupted by a balanced translocation in an XLIS patient that encodes a novel 40 kDa predicted protein named Doublecortin, which may define an Abl-dependent pathway regulating neuronal migration.

TL;DR: The cloning of a gene (LIS-1, lissencephaly-1) in 17p13.3 that is deleted in Miller–Dieker patients is reported, identifying LIS-l as the disease gene and the deduced amino-acid sequence shows significant homology to β-subunits of heterotrimeric G proteins, suggesting that it could possibly be involved in a signal transduction pathway crucial for cerebral development.