Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons.
Fiona Francis,Annette Koulakoff,Dominique Boucher,Philippe Chafey,Bruce T. Schaar,M C Vinet,Gaëlle Friocourt,Nathalie McDonnell,Orly Reiner,Axel Kahn,Susan K. McConnell,Yoheved Berwald-Netter,Philippe Denoulet,Jamel Chelly +13 more
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TL;DR: It is shown that Doublecortin is expressed in the brain throughout the period of corticogenesis in migrating and differentiating neurons, and Immunohistochemical studies show its localization in the soma and leading processes of tangentially migrating neuron, and a strong axonal labeling is observed in differentiating neuron.
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About: This article is published in Neuron. The article was published on 01 Jun 1999. and is currently open access. The article focuses on the topics: Doublecortin & Corticogenesis.
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Citations
Androgens and Estrogens Synergistically Regulate the Expression of Doublecortin and Enhance Neuronal Recruitment in the Song System of Adult Female Canaries
TL;DR: DHT and E2 by themselves increase density of DCX cells migrating through HVC but are not sufficient in isolation to induce the recruitment of these newborn neurons in the nucleus, implying that steroids only act on the attraction and recruitment of new neurons in HVC without having any major effects on their production at the ventricle wall.
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TL;DR: The number of OB interneurons following reduced SVZ proliferation is maintained through an increased survival of adult-born precursor cells, neuroblasts and interneURons.
PBX1 as Pioneer Factor: A Case Still Open
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Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
TL;DR: The SVZa appears to constitute a specialized source of neuronal progenitor cells that differentiated into granule cells and periglomerular cells of the olfactory bulb-the two major types of interneurons.
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A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
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TL;DR: The reeler phenotype seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin.
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Chain Migration of Neuronal Precursors
TL;DR: Electron microscopic analysis of serial sections showed that during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.
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doublecortin, a Brain-Specific Gene Mutated in Human X-Linked Lissencephaly and Double Cortex Syndrome, Encodes a Putative Signaling Protein
Joseph G. Gleeson,Joseph G. Gleeson,Kristina M. Allen,Jeremy W. Fox,Edward D Lamperti,Samuel F. Berkovic,Ingrid E. Scheffer,Edward C. Cooper,William B. Dobyns,Sharon R. Minnerath,M. Elizabeth Ross,Christopher A. Walsh +11 more
TL;DR: A novel 10 kb brain-specific cDNA interrupted by a balanced translocation in an XLIS patient that encodes a novel 40 kDa predicted protein named Doublecortin, which may define an Abl-dependent pathway regulating neuronal migration.
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Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats
Orly Reiner,Romeo Carrozzo,Ying Shen,Manfred Wehnert,Fabrizia Faustinella,William B. Dobyns,C. Thomas Caskey,David H. Ledbetter +7 more
TL;DR: The cloning of a gene (LIS-1, lissencephaly-1) in 17p13.3 that is deleted in Miller–Dieker patients is reported, identifying LIS-l as the disease gene and the deduced amino-acid sequence shows significant homology to β-subunits of heterotrimeric G proteins, suggesting that it could possibly be involved in a signal transduction pathway crucial for cerebral development.
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