Dopamine-mediated regulation of corticostriatal synaptic plasticity

TL;DR: The contrast provided by these studies has provided new insights into how the striatum responds to fluctuations in DA signaling and how diseases that alter this signaling change striatal function.

TL;DR: Findings demonstrating functional and structural plasticity across different spatial and temporal scales that mediate motor skill learning are reviewed while identifying converging areas of interest and possible avenues for future research.

TL;DR: DA plays complementary roles in these two types of MSN to ensure that synaptic plasticity is bidirectional and Hebbian, leading to unidirectional changes in plasticity that could underlie network pathology and symptoms in Parkinson's disease.

TL;DR: It is shown that long-term alterations in dopamine signaling produce profound and cell-type-specific reshaping of corticostriatal connectivity and function and the influence of DA on synaptic plasticity.

TL;DR: It is shown that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism, and these findings indicate that loss ofDJ-1 function leads to neurodegeneration.

TL;DR: A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.

TL;DR: Recent neurophysiological studies reveal that neurons in certain brain structures carry specific signals about past and future rewards, and the optimal use of rewards in voluntary behavior would benefit from interactions between the signals.

TL;DR: This work scanned human participants with functional magnetic resonance imaging while they engaged in instrumental conditioning to suggest partly dissociable contributions of the ventral and dorsal striatum to the critic and the actor.