Journal Article10.1146/ANNUREV.IMMUNOL.21.120601.141135
Does the Immune System See Tumors as Foreign or Self
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TL;DR: To elude immune surveillance, tumors must develop mechanisms that block the elaboration and sensing of proinflammatory danger signals, thereby shifting the balance from activation to tolerance induction.
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Abstract: Given the vast number of genetic and epigenetic changes associated with carcinogenesis, it is clear that tumors express many neoantigens. A central question in cancer immunology is whether recognition of tumor antigens by the immune system leads to activation (i.e., surveillance) or tolerance. Paradoxically, while strong evidence exists that specific immune surveillance systems operate at early stages of tumorigenesis, established tumors primarily induce immune tolerance. A unifying hypothesis posits that the fundamental processes of cancer progression, namely tissue invasion and metastasis, are inherently proinflammatory and thus activating for innate and adaptive antitumor immunity. To elude immune surveillance, tumors must develop mechanisms that block the elaboration and sensing of proinflammatory danger signals, thereby shifting the balance from activation to tolerance induction. Elucidation of these mechanisms provides new strategies for cancer immunotherapy.
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References
•Journal Article
Major histocompatibility complex class I and unique antigen expression by murine tumors that escaped from CD8+ T-cell-dependent surveillance.
TL;DR: It is shown that UV-induced regressor tumors regularly grew progressively and killed mice that were depleted of CD8+ T-cells, suggesting that CD8- but not CD4-cells were required for this immune surveillance.
101
The Nude Mouse vs. The Hypothesis of Immunological Surveillance
Josrgen Rygaard,Carl O. Povlsen +1 more
TL;DR: It is argued that the microbiological milieu and not spontaneous tumour generation is the selective pressure that has maintained cell-mediated immunity during evolution.
100
•Journal Article
Reduced membrane major histocompatibility complex class I density and stability in a subset of human renal cell carcinomas with low TAP and LMP expression.
TL;DR: An important role of the genes of the antigen presentation machinery in stable and efficient MHC class I surface expression of RCC cells is suggested, however, it has still to be defined whether deficient antigen processing is one of the mechanisms of R CC cells to escape the surveillance of the immune system.
96
Comparative analysis of the in vivo expression of tyrosinase, MART-1/Melan-A, and gp100 in metastatic melanoma lesions: implications for immunotherapy.
Janice N. Cormier,Andrea Abati,Patricia Fetsch,Yasmine M. Hijazi,Steven A. Rosenberg,Francesco M. Marincola,Suzanne L. Topalian +6 more
TL;DR: Although threshold levels of Ag required for T-cell recognition have not yet been defined, tumor-associated Ag expressed in high density, such as tyrosinase, may be better targets for future immunotherapy trials.
96
Short-term kinetics of tumor antigen expression in response to vaccination.
Galen A. Ohnmacht,Ena Wang,Simone Mocellin,Andrea Abati,Armando C. Filie,Patricia Fetsch,Adam I. Riker,Udai S. Kammula,Steven A. Rosenberg,Francesco M. Marincola +9 more
TL;DR: An insight into the natural history of tumors is provided and a strategy for the characterization of gene expression in tumors during therapy is defined to suggest that vaccination triggers a broad inflammatory reaction that can lead to tumor destruction despite immune selection.
93
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