Journal Article10.1021/ACS.CHEMREV.7B00663
DNA Nanotechnology-Enabled Drug Delivery Systems
897
TL;DR: The origin of DNA nanotechnology is reviewed, followed by summarizing state-of-the-art strategies for the construction of DNAnanostructures and drug payloads delivered by DNA nanovehicles and challenges and opportunities for DNA nanostructure-based drug delivery.
read more
Abstract: Over the past decade, we have seen rapid advances in applying nanotechnology in biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging field, DNA nanotechnology offers simple yet powerful design techniques for self-assembly of nanostructures with unique advantages and high potential in enhancing drug targeting and reducing drug toxicity. Various sequence programming and optimization approaches have been developed to design DNA nanostructures with precisely engineered, controllable size, shape, surface chemistry, and function. Potent anticancer drug molecules, including Doxorubicin and CpG oligonucleotides, have been successfully loaded on DNA nanostructures to increase their cell uptake efficiency. These advances have implicated the bright future of DNA nanotechnology-enabled nanomedicine. In this review, we begin with the origin of DNA nanotechnology, followed by summarizing state-of-the-art strategies for the construction of DNA nanostructures and drug payloads delivered ...
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Photoluminescent and Chromic Nanomaterials for Anticounterfeiting Technologies: Recent Advances and Future Challenges.
TL;DR: This review would help scientists to design and develop the most applicable encryption, authentication, and anticounterfeiting technologies with high security, fast detection, and potential applications in security marking and information encryption on various substrates.
443
DNA Functional Materials Assembled from Branched DNA: Design, Synthesis, and Applications.
TL;DR: It is envisioned that branched DNA functional materials can not only enrich the DNA nanotechnology by ingenious design and synthesis but also promote the development of interdisciplinary fields in chemistry, biology, medicine, and engineering, ultimately addressing the growing demands on biological and medical-related applications in the real world.
402
DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury.
Dawei Jiang,Zhilei Ge,Hyung Jun Im,Hyung Jun Im,Christopher G. England,Dalong Ni,Junjun Hou,Luhao Zhang,Luhao Zhang,Christopher J. Kutyreff,Yongjun Yan,Yan Liu,Steve Y. Cho,Jonathan W. Engle,Jiye Shi,Peng Huang,Chunhai Fan,Hao Yan,Weibo Cai +18 more
TL;DR: Radiolabelled DNA origami nanostructures with rectangular, triangular and tubular shapes have renal-protective properties, with efficacy similar to the antioxidant N-acetylcysteine—a clinically used drug that ameliorates contrast-induced AKI and protects kidney function from nephrotoxic agents.
354
Lipids and Lipid Derivatives for RNA Delivery
TL;DR: In this article, a review of lipid-based RNA delivery systems is presented, focusing mainly on their chemical structures, synthetic routes, characterization, formulation methods, and structure-activity relationships.
339
Supramolecular cancer nanotheranostics
TL;DR: In this paper, the authors summarized the progress of supramolecular cancer nanotheranostics and provided guidance for designing new targeted theranostic agents based on extensive state-of-the-art research.
328
References
Tumor-Penetrating Peptide-Modified DNA Tetrahedron for Targeting Drug Delivery.
TL;DR: It is found that the DNA tetrahedron plays the main role in the endocytosis of U87MG cells, whereas the tumor-penetrating peptide could also bind to transmembrane glycoprotein neuropilin-1 and mediate the endocytes of the p-TDN nanostructure.
139
Symmetry controls the face geometry of DNA polyhedra.
TL;DR: Two complementary strategies have been developed to control the face geometry during the self-assembly of DNA polyhedra from branched DNA nanomotifs (tiles), where each face must contain an even number of tiles.
136
Receptor-mediated Endocytosis Is Not Required for Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis
TL;DR: Tumor necrosis factor-related apoptosis-inducing ligand and TRAIL receptor 1/2, unlike TNF-TNF-R1 or CD95L-CD95, do not require internalization for formation of the DISC, activation of caspase-8, or transmission of an apoptotic signal in BJAB type I cells.
136
Folding super-sized DNA origami with scaffold strands from long-range PCR
TL;DR: A 26 kilobase single strand DNA fragment was obtained from long-range PCR amplification and subsequent enzymatic digestion, which was folded into a super-sized DNA origami nanostructure by using ∼800 staple strands.
134
Intracellular Delivery of a Planar DNA Origami Structure by the Transferrin‐Receptor Internalization Pathway
David Schaffert,Anders H. Okholm,Rasmus Schøler Sørensen,Jesper Sejrup Nielsen,Thomas Tørring,Christian B. Rosen,Anne Louise Bank Kodal,Michael Rosholm Mortensen,Kurt V. Gothelf,Jørgen Kjems +9 more
TL;DR: A significant strong increase in cellular uptake in an established cancer cell line is demonstrated by modifying a planar DNA origami structure with the iron transport protein transferrin.
134