Journal Article10.1038/S41576-018-0004-3
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
Steve Horvath,Ken Raj +1 more
2.3K
TL;DR: Biomarkers of ageing based on DNA methylation data enable accurate age estimates for any tissue across the entire life course and link developmental and maintenance processes to biological ageing, giving rise to a unified theory of life course.
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Abstract: Identifying and validating molecular targets of interventions that extend the human health span and lifespan has been difficult, as most clinical biomarkers are not sufficiently representative of the fundamental mechanisms of ageing to serve as their indicators. In a recent breakthrough, biomarkers of ageing based on DNA methylation data have enabled accurate age estimates for any tissue across the entire life course. These ‘epigenetic clocks’ link developmental and maintenance processes to biological ageing, giving rise to a unified theory of life course. Epigenetic biomarkers may help to address long-standing questions in many fields, including the central question: why do we age?
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Hormone therapy in the postmenopausal years: considering benefits and risks in clinical practice.
TL;DR: The most significant clinical literature on the effects of hormones in postmenopausal women, and to report the benefits and risks of Hormone therapy for the relief of menopausal symptoms is presented in this paper.
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Cell division drives DNA methylation loss in late-replicating domains in primary human cells
TL;DR: In this article , the authors present experimental evidence that DNA hypomethylation is directly driven by proliferation-associated DNA replication within partially methylated domains (PMDs), late-replicating regions of the genome attached to the nuclear lamina.
Genomics for monitoring and understanding species responses to global climate change.
L. Bernatchez,Anne-Laure Ferchaud,Chloé Suzanne Berger,Clare J. Venney,Amanda T. J. Xuereb +4 more
TL;DR: Methods that apply and integrate omics tools to experimentally investigate, monitor and predict how species and communities in the wild cope with global climate change, which is by genetically adapting to new environmental conditions, through range shifts or through phenotypic plasticity are summarized.
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Developmental programming of aging trajectory.
TL;DR: Experimental and epidemiological evidence on the role of early-life conditions in programming of aging phenotypes are presented and mechanisms potentially underlying these associations are discussed.
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Body mass index is associated with epigenetic age acceleration in the visceral adipose tissue of subjects with severe obesity.
Juan de Toro-Martín,Frédéric Guénard,André Tchernof,Frédéric-Simon Hould,Stéfane Lebel,François Julien,Simon Marceau,Marie-Claude Vohl +7 more
TL;DR: The results suggest that obesity is associated with epigenetic age acceleration of metabolically active tissues, and further studies that deepen the physiological relevance of VAT epigenetic aging will help to better understand the onset of metabolic syndrome and weight loss dynamics following bariatric surgery.
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