Patent
Dna encoding bactericidal/permeability-increasing proteins
Peter Elsbach,Jerrold Weiss +1 more
- 11 Dec 1991
59
TL;DR: A purified, isolated DNA sequence encoding human bactericidal/permeability-increasing protein and biologically active fragments thereof is provided in this article, where the protein is encoded by a protein-protein pair.
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Abstract: A purified, isolated DNA sequence encoding human bactericidal/permeability-increasing protein and biologically-active fragments thereof is provided.
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Citations
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Therapeutic uses of bactericidal/permeability increasing protein products
William Steve Ammons,Little Roger G +1 more
- 11 Mar 1994
TL;DR: In this paper, a method for treatment of conditions including neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and endothelial cell proliferation, and treatment of chronic inflammatory diseases by administration of bactericidal/permeability-increasing protein products is presented.
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Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
II Roger G. Little
- 11 Mar 1994
TL;DR: In this paper, the authors provide peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses, including bactericidal and permeability-increasing protein (BPI) functional domains.
72
References
Cellular and subcellular localization of the bactericidal/permeability-increasing protein of neutrophils.
TL;DR: Findings indicate that BPI is a specific product of the neutrophil lineage and, hence, of the specialized cytotoxic apparatus of the Neutrophil that plays an essential role in host defense v gram-negative bacteria.
228
Patent
Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders
Marian N. Marra,Randal W. Scott +1 more
- 22 Jan 1990
TL;DR: In this article, a method of inhibiting lipopolysaccharide (LPS)-mediated stimulation of cells was proposed, which consisted of contacting the cells, in the presence of a cell-stimulating amount of lip-saccharides, with Bactericidal/Permeability increasing protein (BPI) in an amount effective to inhibit cell stimulation.
53
Patent
Antimicrobial proteins, compositions containing same and uses thereof
Joelle E. Gabay,Carl Nathan +1 more
- 25 Nov 1987
TL;DR: In this paper, the authors presented a composition of matter useful as an antimicrobial agent, which consisted of at least two polypeptides selected from the group consisting of human polymorphonuclear leukocyte, polypeps having on apparent molecular weights of about 3,500 daltons, about 13,000 dalton, about 18,000daltons and about 29,000 Daltons.
51
Patent
Recombinant, non-glycosylated bpi protein and uses thereof
Randal W. Scott,Marian N. Marra +1 more
- 14 Dec 1992
TL;DR: In this paper, a method for preventing endotoxin-associated shock in a subject which comprises administering to the subject an amount of a BPI protein effective to bind to endotoxin so as to prevent endotoxin associated shock in the subject.
47
•Journal Article
A monoclonal antibody that inhibits the antimicrobial action of a 57 KD cationic protein of human polymorphonuclear leukocytes.
TL;DR: Two monoclonal antibodies specific for epitopes of a 57,000 m.w., cationic antimicrobial protein purified from granules of human polymorphonuclear leukocytes (PMN) have been produced and Binding constants of the two mAb for the antigen were determined and were found to be virtually identical.
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