Open AccessJournal Article
DNA-cytometric detection of euploid polyploidization in oral lichen ruber planus.
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TL;DR: In this article, the DNA distribution was analyzed in 29 cases of oral lichen ruber planus that were negative for human papillomavirus and not suspected of being precancerous.
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Abstract: The DNA distribution was analyzed in 29 cases of oral lichen ruber planus that were negative for human papillomavirus and not suspected of being precancerous. Monolayer smears prepared from formalin-fixed, paraffin-embedded tissues were automatically Feulgen stained and used for rapid interactive DNA cytometry via a TV-based image analysis system combined with an automated microscope. Nuclei with DNA contents greater than 4c were found in 25 cases (86%). DNA contents greater than 8c were seen in five cases (17%), and small peaks at 8c were found in three cases. These increased DNA values in nonprecancerous lesions must be interpreted as euploid polyploidization and have to be taken into account if DNA measurements are performed for diagnostic purposes in lichen ruber planus lesions that are suspected of having malignant transformation.
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Citations
Cytologic and DNA-Cytometric Early Diagnosis of Oral Cancer
Torsten W. Remmerbach,Horst Weidenbach,Natalja Pomjanski,Kristiane Knops,Stefanie Mathes,Alexander Hemprich,Alfred Böcking +6 more
TL;DR: Brush cytology of all visible oral lesions, if they are clinically considered as suspicious for cancer, are an easily practicable, cheap, non‐invasive, painless, safe and accurate screening method for detection of oral precancerous lesions, carcinoma in situ or invasive squamous cell carcinomas in all stages.
Polyploidy in non-neoplastic tissues.
TL;DR: Polyploidy in the liver may be interpreted as being associated with tissue differentiation, but the findings in urothelium and mesothelium remain of unknown importance.
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DNA content, Cyclooxygenase-2 expression and loss of E-cadherin expression do not predict risk of malignant transformation in oral lichen planus.
TL;DR: Neither aneuploidy, Cox-2 expression, nor loss of E-cadherin expression were significant reliable markers to select OLP lesions at risk for development of OSCC in the present patient material.
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Equivocal cytology in lung cancer diagnosis: improvement of diagnostic accuracy using adjuvant multicolor FISH, DNA-image cytometry, and quantitative promoter hypermethylation analysis.
Martin Schramm,Christian Wrobel,Ingmar Born,Marietta Kazimirek,Natalia Pomjanski,Marina William,Rainer Kappes,Claus Dieter Gerharz,Stefan Biesterfeld,Alfred Böcking +9 more
TL;DR: FISH, fluorescent in situ hybridization (FISH), DNA‐image cytometry, and quantitative promoter hypermethylation analysis have been proposed as adjuncts to enhance diagnostic accuracy.
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Aneuploidy in actinic keratosis and Bowen's disease—increased risk for invasive squamous cell carcinoma?
TL;DR: The frequent occurrence of aneuploidy in actinic keratoses and Bowen's disease underlines the character of the lesions as epidermal carcinomas in situ, but does not explain the long‐term low incidence of invasive growth.
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