Patent
DNA-based vaccination of fish
Heather L. Davis
- 04 Nov 1996
232
TL;DR: In this article, the authors proposed methods of immunization of aquaculture species by introducing DNA expression systems into the aquaulture species, which are useful for prophylactic vaccination or therapeutic immunization for finfish, shellfish, or other aquatic animals against infectious diseases.
read more
Abstract: The present invention relates to methods of immunization of aquaculture species by introducing DNA expression systems into the aquaculture species. Such DNA expression systems preferably include DNA sequences encoding polypeptides of pathogens of species of aquaculture. The present invention also relates to methods of administration of DNA expression systems into aquaculture. Such methods include injection, spray, and immersion techniques. The methods of this invention are useful for prophylactic vaccination or therapeutic immunization of fin-fish, shellfish, or other aquatic animals against infectious diseases.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Patent
Synergistic improvements to polynucleotide vaccines
Eyal Raz,Kenji Takabayashi,Minh-Duc Nguyen +2 more
- 06 Apr 2001
TL;DR: The polynucleotide vaccine of as mentioned in this paper is a polynomial vaccine with an immunostimulatory sequence adjuvant to not only maintain, but to enhance, the immune response to the encoded antigen.
29
Patent
Immunogenic complexes and methods relating thereto
John Cooper Cox,Debbie Drane,Andreas Suhrbier +2 more
- 17 Feb 2000
TL;DR: In this paper, an immunogenic complex consisting of a charged organic carrier and a charged antigen was proposed for facilitating the induction of a cytotoxic T-lymphocyte response to an antigen.
29
Patent
Dissolved Oxygen Control System for Aquaculture
Jr. Robert W. Stiles,Dennis P. Delong,Thomas M. Losordo +2 more
- 17 Mar 2014
TL;DR: In this paper, a recirculating aquaculture system for aquatic life is described, which includes a culture tank, a sensor configured to measure a current dissolved oxygen level in the culture tank and a variable speed pump configured to circulate water through the tank.
28
Patent
Methods and compositions related to immunizing against staphylococcal lung diseases and conditions
Juliane Bubeck-Wardenburg,Olaf Schneewind,Brook Ragle +2 more
- 29 Aug 2008
TL;DR: In this article, a recombinant mutant form of HIa (HlaH35L) is presented, in which histidine 35 is converted to leucine, which can be used to abrogate the productive assembly of the toxin and protect a subject from staphylococcal pneumonia.
27
Patent
Reprogramming t cells and hematopoietic cells
Matthew E. Brown,Elizabeth Rondon Dominguez,Randy Learish,Emile Nuwaysir,Deepika Rajesh,Amanda Mack +5 more
- 04 Jun 2010
TL;DR: In this paper, methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed, and various iPS cell lines are also provided.
26
References
Direct gene transfer into mouse muscle in vivo.
Jon A. Wolff,Robert W. Malone,Phillip Williams,Wang Chong,Gyula Acsadi,Agnes Jani,Philip L. Felgner +6 more
TL;DR: RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were separately injected into mouse skeletal muscle in vivo and expression was comparable to that obtained from fibroblasts transfected in vitro under optimal conditions.
4.4K
Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization
Yukio Sato,Mark Roman,H Tighe,Delphine J. Lee,Maripat Corr,Minh-Duc Nguyen,Gregg J. Silverman,Martin Lotz,Dennis A. Carson,Eyal Raz +9 more
TL;DR: Although ISS are necessary for gene vaccination, they down-regulate gene expression and thus may interfere with gene replacement therapy by inducing proinflammatory cytokines.
1.2K
Direct gene transfer into skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression.
TL;DR: It is determined that much of the variability of expression is due to nonuniform distribution of substances injected into skeletal muscle in vivo, and a model to ameliorate this is developed.
519
In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment.
TL;DR: The particle bombardment method of gene transfer provides an alternative approach for analysis of in vivo promoter activity and transgene expression in mouse, rabbit, and rhesus monkey tissues and suggests that particle bombardment provides an effective system for studies of in vitro gene transfer and gene therapy.
361
Plasmid DNA Is Superior to Viral Vectors for Direct Gene Transfer into Adult Mouse Skeletal Muscle
TL;DR: The surprisingly high relative efficiency of pure plasmid DNA suggests that this method will provide a simple, safe and viable alternative for gene therapy involving muscle tissue.
339