Journal Article10.1039/C5RA02553B
Disulfide cross-linked cholic-acid modified PEG–poly(amino acid) block copolymer micelles for controlled drug delivery of doxorubicin
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TL;DR: Reduction responsive biodegradable core-cross-linked micelles developed form lipoic acid and cholic acid (CA) decorated poly(ethylene glycol)-b-poly(L-glutamic acid) block copolymers have great potential for drug delivery in cancer chemotherapy.
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Abstract: Reduction responsive biodegradable core-cross-linked micelles are developed form lipoic acid (LA) and cholic acid (CA) decorated poly(ethylene glycol)-b-poly(L-glutamic acid) (PEG-pGlu(EDA-LA)-CA) block copolymers and investigated for intracellular doxorubicin (DOX) release. The amphiphilic polymers can self-assemble into nano-sized core–shell micelles that are easily cross-linked in the presence of a catalytic amount of dithiothreitol (DTT). The cross-linked micelles (CLM) show excellent stability against extensive dilution and high salt concentration but rapid dissociation and drug release in reductive environments. Confocal laser scanning microscopy further demonstrates that DOX was delivered and released into the nuclei of HeLa cells following 8 h incubation with DOX-loaded CLM. MTT assays reveal that DOX-loaded CLM had similar anti-tumor activity to non-cross-linked micelles (NCLM) for HeLa cells following 48 h incubation, while blank micelles were practically nontoxic up to a tested concentration of 1.0 mg mL−1. These reduction responsive core-cross-linked micelles have great potential for drug delivery in cancer chemotherapy.
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Polymer‐based drug delivery systems for cancer treatment
TL;DR: This review is focused on the chemical design and synthesis of polymer-based drug delivery systems, in particular with stimuli-responsive nanoplatforms for cancer treatment, and provides a brief description of the properties, synthesis and advantages of amphiphilic block copolymers, including polyether-polyester and poly ether-polyanhydride.
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Construction of redox/pH dual stimuli-responsive PEGylated polymeric micelles for intracellular doxorubicin delivery in liver cancer
TL;DR: The successful demonstrations indicate that redox and pH dual-responsive mPEG-SS-PNLG micelles are promising candidates for delivering anti-cancer drugs.
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Design and strategies for bile acid mediated therapy and imaging
Nurunnabi,Nurunnabi,Zehedina Khatun,Vishnu Revuri,Nafiujjaman,Seungbin Cha,Sungpil Cho,Kang Moo Huh,Yong-kyu Lee +8 more
TL;DR: The opinions regarding the utilization of bile acids for biological and biomedical applications provide clear and concise guidance to investigators with respect to the merits and demerits of bILE acid use and the selection of appropriate bile acid based on the requirements for improved biomedical applications.
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PDEAEMA-based pH-sensitive amphiphilic pentablock copolymers for controlled anticancer drug delivery
TL;DR: The results indicate that this new kind of amphiphilic copolymers could serve as promising nanocarriers for controlled anticancer drug delivery.
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Folic Acid-Conjugated pH and Redox-Sensitive Ellipsoidal Hybrid Magnetic Nanoparticles for Dual-Triggered Drug Release
Gökçen Birlik Demirel,Ebru Aygul,Ebru Aygul,Aydan Dağ,Sezen Atasoy,Zeynep Cimen,Zeynep Cimen,Busra Cetin,Busra Cetin +8 more
- 05 Aug 2020
TL;DR: Pimuli-sensitive and multifunctional nanoparticles are highly desirable biomedical materials for triggered and targeted drug delivery applications and pH- and redox-triggered nanoparticles for these materials have been designed.
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