Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type
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TL;DR: It is shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions and the association of the hyphalphase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. Neoformans.
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Abstract: Cryptococcus neoformans is a major opportunistic fungal pathogen in AIDS and other immunosuppressed patients. We have shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions. Hyphae produced under these conditions are monokaryotic, possess unfused clamp connections, and develop basidia with viable basidiospores. The ability to undergo this transition is determined by the presence of the alpha-mating type locus and is independent of serotype. The association of the hyphal phase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. neoformans.
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Citations
Impact of Mating Type, Serotype, and Ploidy on the Virulence of Cryptococcus neoformans
Xiaorong Lin,Kirsten Nielsen,Joseph Heitman +2 more
TL;DR: In vitro and in vivo characterization of laboratory-constructed isogenic diploids and AD hybrids with all possible mating type combinations in defined genetic backgrounds are used and it is found that higher ploidy has a minor negative effect on virulence in a murine inhalation model of cryptococcosis.
Genomic evidence for a complete sexual cycle in Candida albicans
Keh-Weei Tzung,Roy Williams,Stewart Scherer,Nancy A. Federspiel,Ted Jones,Nancy F. Hansen,Vesna Bivolarevic,Lucas Huizar,Caridad Komp,Ray Surzycki,Raquel Tamse,Ronald W. Davis,Nina Agabian +12 more
TL;DR: Analyzing over 500 genes important for sexual differentiation in S. cerevisiae, many homologues of genes that are implicated in the initiation of meiosis, chromosome recombination, and the formation of synaptonemal complexes are found, but others are striking in their absence.
Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans.
TL;DR: The MFα pheromone was not essential for virulence of C. neoformans but does contribute to the overall virulence composite, and these studies define paracrine and autocrine peromone response pathways that signal mating and differentiation of this pathogenic fungus.
Mixed infections and in vivo evolution in the human fungal pathogen Cryptococcus neoformans.
Marie Desnos-Ollivier,Marie Desnos-Ollivier,Sweta M. Patel,Sweta M. Patel,Adam R. Spaulding,Caroline Charlier,Caroline Charlier,Dea Garcia-Hermoso,Dea Garcia-Hermoso,Kirsten Nielsen,Françoise Dromer,Françoise Dromer +11 more
- 01 Jan 2010
TL;DR: It is demonstrated that mixed infections in humans are more common than previously thought, occurring in almost 20% of patients diagnosed with cryptococcosis, and the concept of one strain causing one infection does not hold true for C. neoformans and may apply to other environmentally acquired fungal pathogens.
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