Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type
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TL;DR: It is shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions and the association of the hyphalphase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. Neoformans.
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Abstract: Cryptococcus neoformans is a major opportunistic fungal pathogen in AIDS and other immunosuppressed patients. We have shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions. Hyphae produced under these conditions are monokaryotic, possess unfused clamp connections, and develop basidia with viable basidiospores. The ability to undergo this transition is determined by the presence of the alpha-mating type locus and is independent of serotype. The association of the hyphal phase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. neoformans.
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Citations
•Dissertation
Disconnecting a role for DNA repair in the pathogenicity of the human pathogen Cryptococcus neoformans
Surbhi Verma
- 01 Jan 2014
TL;DR: DNA repair strategies adopted by Cryptococcus to survive in the environment and to cause successful infection are investigated and it is suggested that UVE1 is required to combat UV induced stress.
3
Cryptococcus neoformans e cryptococcus gattii: perspectivas sobre a eco-epidemiologia e novos nichos ecológicos
Tatiana Carolina Dias Pereira,Rosângela Abreu Monteiro De Barros +1 more
- 18 Sep 2012
TL;DR: Os dados encontrados neste estudo abrem uma interessante perspectiva sobre a ecoepidemiologia do Cryptococcus gattii, uma vez that verificou-se that sua presenca nao esta associada apenas a nichos ecologicos especificos, podendo ser encontrado em diferentes regioes e arvores.
3
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