Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type
316
TL;DR: It is shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions and the association of the hyphalphase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. Neoformans.
read more
Abstract: Cryptococcus neoformans is a major opportunistic fungal pathogen in AIDS and other immunosuppressed patients. We have shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions. Hyphae produced under these conditions are monokaryotic, possess unfused clamp connections, and develop basidia with viable basidiospores. The ability to undergo this transition is determined by the presence of the alpha-mating type locus and is independent of serotype. The association of the hyphal phase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. neoformans.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Theoretical population genetics of mating-type linked haplo-lethal alleles
TL;DR: A theoretical model is developed that shows how haplo-lethal alleles may spread if they provide a compensatory advantage in the diploid or dikaryotic phase, for example, through increased disease transmission.
27
Terbinafine inhibits Cryptococcus neoformans growth and modulates fungal morphology
TL;DR: The in vitro effect of terbinafine (TRB), an antifungal not commonly used to treat cryptococcosis, is evaluated and the use of TRB alone or in combination with AMB and azoles should be explored as an alternative treatment for cryptococcotic patients who do not respond to standard therapies.
27
Doing it alone : unisexual reproduction in filamentous ascomycete fungi
Andi M. Wilson,Raphael Gabriel,Steven W. Singer,Timo Schuerg,P. Markus Wilken,Magriet A. van der Nest,Michael J. Wingfield,Brenda D. Wingfield +7 more
TL;DR: Comparing genetic, genomic and transcriptomic data from a variety of unisexual species to similar data from their primary homothallic and heterothallic relatives shows that unisexual reproduction is likely derived from heterothallism via the mutation of genes involved in the initiation of sexual reproduction.
27
AreA controls nitrogen source utilisation during both growth programs of the dimorphic fungus Penicillium marneffei
TL;DR: It is proposed that AreA is likely to contribute to the pathogenicity of P. marneffei by facilitating growth in the host environment and regulating the expression of potential virulence factors such as extracellular proteases.
26
The α-Specific Cell Identity Factor Sxi1α Is Not Required for Virulence of Cryptococcus neoformans
TL;DR: These studies reveal that the only known α-specific factor, SXI1α, is not necessary for virulence, and therefore α strains are not more virulent than a strains.
26
References
Genetic association of mating types and virulence in Cryptococcus neoformans.
TL;DR: Testing for virulence in mice suggested the genetic association of virulence with mating type in this human fungal pathogen alpha type was clearly more virulent than a type.
442
A new genus, filobasidiella, the perfect state of Cryptococcus neoformans.
TL;DR: Differences in the manner of basidiospores formation in species of Filobasidium is not repetitious, whereas the new basidiomycete forms basidiaospores in basipetal chains by repetitious budding to warrant description of a new genus.
408
Distribution of alpha and alpha mating types of Cryptococcus neoformans among natural and clinical isolates.
K. J. Kwon-Chung,John E. Bennett +1 more
TL;DR: Survey revealed that the mating type alpha is predominant among natural and clinical isolates of Cryptococcus neoformans regardless of the serotype.
266
Distribution and deposition of inhaled particles in respiratory tract.
TL;DR: Total respiratory retention is the sum of the separate fractions of particles deposited at different sites within the respiratory system, and useful distinction being made between total, upper respiratory, and deep-lung deposition.
189
Aspergillus nidulans apsA (anucleate primary sterigmata) encodes a coiled-coil protein required for nuclear positioning and completion of asexual development.
Reinhard Fischer,W E Timberlake +1 more
TL;DR: There is a stringent developmental requirement for apsA function, but only at the stage of primary bud formation, and it is shown that occasionally in mutants a nucleus enters a primary bud and this event relieves the developmental blockage.