Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type
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TL;DR: It is shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions and the association of the hyphalphase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. Neoformans.
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Abstract: Cryptococcus neoformans is a major opportunistic fungal pathogen in AIDS and other immunosuppressed patients. We have shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions. Hyphae produced under these conditions are monokaryotic, possess unfused clamp connections, and develop basidia with viable basidiospores. The ability to undergo this transition is determined by the presence of the alpha-mating type locus and is independent of serotype. The association of the hyphal phase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. neoformans.
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Citations
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30
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TL;DR: In this paper, a review summarizes recent discoveries on the regulation of cryptococcal life cycle and morphogenesis, and how they impact the pathogenicity of C. neoformans.
29
cAMP/PKA signalling pathway regulates redox homeostasis essential for Sporisorium scitamineum mating/filamentation and virulence.
Changqing Chang,Enping Cai,Yi Zhen Deng,Dan Mei,Qiu Shanxu,Baoshan Chen,Lian-Hui Zhang,Zide Jiang +7 more
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29
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