Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type
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TL;DR: It is shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions and the association of the hyphalphase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. Neoformans.
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Abstract: Cryptococcus neoformans is a major opportunistic fungal pathogen in AIDS and other immunosuppressed patients. We have shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions. Hyphae produced under these conditions are monokaryotic, possess unfused clamp connections, and develop basidia with viable basidiospores. The ability to undergo this transition is determined by the presence of the alpha-mating type locus and is independent of serotype. The association of the hyphal phase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. neoformans.
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Citations
Variability of karyotypes and RAPD types in genetically related strains of Cryptococcus neoformans
Teun Boekhout,Alex van Belkum +1 more
TL;DR: The present data do not support the meiotic maintenance hypothesis, which claims that the amount of CLP generated is inversely proportional to the frequency of meiosis, and three mechanisms may contribute to the karyotype variation of C. neoformans.
Identification of N-acetylneuraminic acid and its 9-O-acetylated derivative on the cell surface of Cryptococcus neoformans: influence on fungal phagocytosis
Marcio L. Rodrigues,Sonia Rozental,José Nelson Couceiro,Jayme Angluster,Celuta S. Alviano,L. R. Travassos +5 more
TL;DR: Results show that sialic acids are components of the cryptococcal cell surface that contribute to its negative charge and protect yeast forms against phagocytosis.
54
Morphology and its underlying genetic regulation impact the interaction between Cryptococcus neoformans and its hosts.
TL;DR: Investigations using the Cryptococcus RAM and ZNF2 mutants indicate that cell shape, cell size, and likely cell surface properties weigh differently on the outcome of cryptococcal interactions with different hosts.
A STE12 Homolog Is Required for Mating but Dispensable for Filamentation in Candida lusitaniae
TL;DR: It is demonstrated that C. lusitaniae is haploid and has a sexual cycle involving mating between MATa and MATalpha cells under nutrient deprivation conditions and both conserved and divergent roles are revealed in regulating differentiation of this emerging fungal pathogen.
53
Transcription Factor STE12α Has Distinct Roles in Morphogenesis, Virulence, and Ecological Fitness of the Primary Pathogenic Yeast Cryptococcus gattii
Ping Ren,Deborah J. Springer,Melissa Behr,William A. Samsonoff,Sudha Chaturvedi,Vishnu Chaturvedi +5 more
TL;DR: The ste12αΔ mutant was markedly attenuated in virulence in both BALB/c and A/Jcr mice models of meningoencephalitis, and it also exhibited significant in vivo growth reduction and was highly susceptible to in vitro killing by human neutrophils (polymorphonuclear leukocytes).
51
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