Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type
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TL;DR: It is shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions and the association of the hyphalphase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. Neoformans.
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Abstract: Cryptococcus neoformans is a major opportunistic fungal pathogen in AIDS and other immunosuppressed patients. We have shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions. Hyphae produced under these conditions are monokaryotic, possess unfused clamp connections, and develop basidia with viable basidiospores. The ability to undergo this transition is determined by the presence of the alpha-mating type locus and is independent of serotype. The association of the hyphal phase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. neoformans.
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Citations
Environmentally controlled dimorphic cycle in a fission yeast
TL;DR: It is shown that the related Schiz.
Microbiological characteristics of clinical isolates of Cryptococcus neoformans in Taiwan: serotypes, mating types, molecular types, virulence factors, and antifungal susceptibility.
Shwu-Jen Liaw,Wu Hc,Po-Ren Hsueh +2 more
TL;DR: The similar profiles of clinical and environmental isolates suggest that patients might acquire these yeasts from the environment, and a correlation between phospholipase activity and the ability to adhere to the lung epithelial cell line, A549 is indicated.
60
Morphogenesis of Cryptococcus neoformans.
TL;DR: Originally described as a yeast-like fungus causing human and animal infections, C. neoformans is now known to undergo morphological transitions that are important for its survival and dissemination.
60
The GATA-type transcriptional activator Gat1 regulates nitrogen uptake and metabolism in the human pathogen Cryptococcus neoformans.
Livia Kmetzsch,Charley Christian Staats,Elisa de Saldanha Simon,Fernanda L. Fonseca,Débora L. Oliveira,Luna S. Joffe,Jéssica Rodrigues,Rogério F. Lourenço,Suely Lopes Gomes,Leonardo Nimrichter,Marcio L. Rodrigues,Augusto Schrank,Marilene Henning Vainstein +12 more
TL;DR: Gat1 is not required for C. neoformans survival during macrophage infection or for virulence in a mouse model of cryptococcosis, and target genes that are regulated by Gat1 in the presence of proline, a poor and non-repressing nitrogen source are identified.
59
Blue light negatively regulates the sexual filamentation via the Cwc1 and Cwc2 proteins in Cryptococcus neoformans.
TL;DR: It is demonstrated that the production of dikaryotic filaments is inhibited by blue light, illustrating blue light negatively regulates the sexual filamentation via the CwC1 and Cwc2 proteins in C. neoformans.
58
References
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K. J. Kwon-Chung,John E. Bennett +1 more
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TL;DR: Total respiratory retention is the sum of the separate fractions of particles deposited at different sites within the respiratory system, and useful distinction being made between total, upper respiratory, and deep-lung deposition.
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