Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type
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TL;DR: It is shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions and the association of the hyphalphase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. Neoformans.
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Abstract: Cryptococcus neoformans is a major opportunistic fungal pathogen in AIDS and other immunosuppressed patients. We have shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions. Hyphae produced under these conditions are monokaryotic, possess unfused clamp connections, and develop basidia with viable basidiospores. The ability to undergo this transition is determined by the presence of the alpha-mating type locus and is independent of serotype. The association of the hyphal phase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. neoformans.
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Citations
Cryptococcus gattii in AIDS Patients, Southern California
TL;DR: A molecular analysis of pheromone genes showed a notable prevalence of Cryptococcus gattii isolates from AIDS patients in southern California.
103
Mixed Infections and In Vivo Evolution in the Human Fungal Pathogen Cryptococcus neoformans
Marie Desnos-Ollivier,Marie Desnos-Ollivier,Sweta M. Patel,Sweta M. Patel,Adam R. Spaulding,Caroline Charlier,Caroline Charlier,Dea Garcia-Hermoso,Dea Garcia-Hermoso,Kirsten Nielsen,Françoise Dromer,Françoise Dromer +11 more
TL;DR: In this paper, the authors found that mixed infections in humans are more common than previously thought, occurring in almost 20% of patients diagnosed with cryptococcosis, and that these mixed infections are composed of different mating types, serotypes, and genotypes.
100
Temperature-regulated transcription in the pathogenic fungus Cryptococcus neoformans.
Barbara R. Steen,Tian Lian,Scott Zuyderduyn,William Kim MacDonald,Marco A. Marra,Steven J.M. Jones,James W. Kronstad +6 more
TL;DR: This work uses serial analysis of gene expression (SAGE) to characterize the transcriptomes of C. neoformans strains that represent two varieties with different polysaccharide capsule serotypes, providing the most comprehensive gene expression data available for this pathogen.
Pathogenicity of basidiospores of Filobasidiella neoformans var. neoformans.
TL;DR: It is proposed that basidiospores are one form of the infectious propagules of F. neo formans var.
97
Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans.
TL;DR: The basidiomycetous yeast Cryptococcus neoformans is a human pathogen defined as virulence traits including the polysaccharide capsule, melanin, and the ability to grow at 37 degreesC and is an excellent model to further dissect virulence-associated signaling pathways.
96
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