Journal Article10.1126/SCIENCE.3952501
Differential conditioning of associative synaptic enhancement in hippocampal brain slices
Stephen R. Kelso,Thomas H. Brown +1 more
TL;DR: H hippocampal synapses in vitro can undergo the conditional and selective type of associative modification that could provide the substrate for some of the mnemonic functions in which the hippocampus is thought to participate.
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Abstract: An electrophysiological stimulation paradigm similar to one that produces Pavlovian conditioning was applied to synaptic inputs to pyramidal neurons of hippocampal brain slices. Persistent synaptic enhancement was induced in one of two weak synaptic inputs by pairing high-frequency electrical stimulation of the weak input with stimulation of a third, stronger input to the same region. Forward (temporally overlapping) but not backward (temporally separate) pairings caused this enhancement. Thus hippocampal synapses in vitro can undergo the conditional and selective type of associative modification that could provide the substrate for some of the mnemonic functions in which the hippocampus is thought to participate.
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Citations
Does associative LTP underlie classical conditioning
TL;DR: This commentary presents an alternative interpretation of the findings based on the hypothesis that an associative LTP-like process occurs during behavioral conditions that produce intense coactivation of different groups of hippocampal synapses, and minimizes fitting models of learning to the temporal constraints of classical conditioning training parameters.
Classical Conditioning Phenomena Predicted by a Drive-Reinforcement Model of Neuronal Function
A. Harry Klopf
- 01 Jan 1989
TL;DR: The ability of the neuronal model to predict animal learning phenomena is improved if, instead of correlating positive and negative changes in neuronal inputs withChanges in neuronal outputs, only positive changes in inputs are correlated with changes in outputs.
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Hebbian Synaptic Plasticity: Evolution of the Contemporary Concept
Thomas H. Brown,Sumantra Chattarji +1 more
- 01 Jan 1994
TL;DR: The contemporary concept of a Hebbian synaptic learning mechanism is summarized and more recent evidence regarding variations and extensions of Hebb’s original postulate for learning is reviewed.
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Fear conditioning model predicts key temporal aspects of conditioned response production
John P. McGann,Thomas H. Brown +1 more
TL;DR: It is shown through computer simulations that the circuit-level model of fear conditioning predicts that these five time-domain phenomena should also be witnessed in longer delay conditioning procedures, provided that a suitable behavioral or neural probe is used.
CHAPTER 18 – Learning and Memory: Basic Mechanisms
Thomas H. Brown,John H. Byrne,Kevin S. LaBar,Joseph E. LeDoux,Derick H. Lindquist,Richard F. Thompson,Timothy J. Teyler +6 more
- 01 Jan 2004
TL;DR: The discovery of long-term synaptic potentiation accomplished the remarkable goal of furnishing a causal connection between the time scale on which neurophysiological events had traditionally been measured and the time Scale over which pertinent forms of learning and memory are studied.
19
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