Journal Article10.1126/SCIENCE.3952501
Differential conditioning of associative synaptic enhancement in hippocampal brain slices
Stephen R. Kelso,Thomas H. Brown +1 more
TL;DR: H hippocampal synapses in vitro can undergo the conditional and selective type of associative modification that could provide the substrate for some of the mnemonic functions in which the hippocampus is thought to participate.
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Abstract: An electrophysiological stimulation paradigm similar to one that produces Pavlovian conditioning was applied to synaptic inputs to pyramidal neurons of hippocampal brain slices. Persistent synaptic enhancement was induced in one of two weak synaptic inputs by pairing high-frequency electrical stimulation of the weak input with stimulation of a third, stronger input to the same region. Forward (temporally overlapping) but not backward (temporally separate) pairings caused this enhancement. Thus hippocampal synapses in vitro can undergo the conditional and selective type of associative modification that could provide the substrate for some of the mnemonic functions in which the hippocampus is thought to participate.
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References
Heterosynaptic depression: a postsynaptic correlate of long-term potentiation
TL;DR: It was found that potentiation of one afferent tended to depress the target cell's responses to a second test input, and theories of long-term potentiation which have evolved from work on invertebrate and neuromusclar preparations may not be appropriate to explain synaptic plasticity in hippocampus.
652
Specific long-lasting potentiation of synaptic transmission in hippocampal slices.
TL;DR: In this paper, the size of two independent afferent inputs is monitored to check for non-specific changes in excitability, and it is suggested that LLP is caused by a specific augmentation of transmitter release.
515
Neurophysiology and pharmacology of long-term potentiation in the rat sympathetic ganglion.
TL;DR: The results indicate that ganglionic l.t.p. is a Ca2+‐ and temperature‐dependent process that can be created independently of the activation of nicotinic, muscarinic or adrenergic receptors.
94
Conductance mechanism responsible for long-term potentiation in monosynaptic and isolated excitatory synaptic inputs to hippocampus.
TL;DR: The biophysical mechanisms underlying long-term potentiation (LTP) were investigated in identifiable and monosynaptic excitatory inputs to hippocampal neurons, providing the first insights into the conductance changes that are responsible for the expression of LTP.
86
Differential effects of Ba2+, Sr2+, and Ca2+ on stimulation-induced changes in transmitter release at the frog neuromuscular junction.
TL;DR: Results provide pharmacological support for the proposal that there are four different components of increased transmitter release associated with repetitive stimulation and suggest that the underlying factors in the nerve terminal that give rise to these components can act somewhat independently of one another.
82