Journal Article10.1007/S11695-016-2399-2
Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission
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TL;DR: Overall, RYGB produces greater and more predicted favourable changes in gut microbiota functional capacity than SG, and is likely to be associated with remission of type 2 diabetes after distinct types of bariatric surgery.
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Abstract: It is unclear whether specific gut microbiota is associated with remission of type 2 diabetes (T2D) after distinct types of bariatric surgery. The aim of this study is to examine gut microbiota changes after laparoscopic Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgery in obese patients with T2D. Whole-metagenome shotgun sequencing of DNA fragments using Illumina HiSeq2000 was obtained from stool samples collected from 14 obese T2D patients pre-operatively (while on very low calorie diet) and 1 year after randomisation to laparoscopic SG (n = 7) or RYGB (n = 7). Resulting shotgun reads were annotated with Kyoto Encyclopedia of Genes and Genomes (KEGG). Body weight reduction and dietary change was similar 1 year after both surgery types. Identical proportions (n = 5/7) achieved diabetes remission (HbA1c < 48 mmol/mol without medications) 1 year after RYGB and SG. RYGB resulted in increased Firmicutes and Actinobacteria phyla but decreased Bacteroidetes phyla. SG resulted in increased Bacteroidetes phyla. Only an increase in Roseburia species was observed among those achieving diabetes remission, common to both surgery types. KEGG Orthology and pathway analysis predicted contrasting and greater gut microbiota metabolism changes after diabetes remission following RYGB than after SG. Those with persistent diabetes post-operatively had higher Desulfovibrio species pre-operatively. Overall, RYGB produces greater and more predicted favourable changes in gut microbiota functional capacity than SG. An increase in Roseburia species was the only compositional change common to both types of surgery among those achieving diabetes remission.
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Citations
Roux-en-Y gastric bypass and sleeve gastrectomy induce substantial and persistent changes in microbial communities and metabolic pathways
Jerry T. Dang,Valentin Mocanu,Heekuk Park,Michael Laffin,Naomi Hotte,Shahzeer Karmali,Daniel W. Birch,Karen L. Madsen +7 more
TL;DR: This work represents comprehensive analyses of microbial-metabolomic changes that occur following bariatric surgery and identifies several pathways that are associated with beneficial metabolic effects of surgery.
Changes in Gut Microbiota Composition after Bariatric Surgery: a New Balance to Decode
Silvia Palmisano,Giuseppina Campisciano,Marta Silvestri,Martina Guerra,Michela Giuricin,Biagio Casagranda,Manola Comar,Nicolò de Manzini +7 more
TL;DR: In this study, Roux-en-Y gastric bypass induced major microbial differences and greater weight loss compared with laparoscopic sleeve gastrectomy, and a proliferation of potential pathogens and the onset of beneficial bacteria was observed.
Shifts in gut microbiota and their metabolites induced by bariatric surgery. Impact of factors shaping gut microbiota on bariatric surgery outcomes
Carolina Gutiérrez-Repiso,Isabel Moreno-Indias,Francisco J. Tinahones,Francisco J. Tinahones +3 more
TL;DR: In this article, the most relevant findings, mainly described in Roux-en-Y gastric bypass and sleeve gastrectomy, are outlined, and the influence of these alterations on host metabolism and the contribution of gut microbiota derived metabolites.
Fecal Bacterial Community and Metagenome Function in Asians with Type 2 Diabetes, According to Enterotypes
Xuangao Wu,Sunmin Park +1 more
TL;DR: The role of gut microbes has been suggested in type 2 diabetes (T2DM) risk as discussed by the authors , and the authors examined the combined data from 36 different T2DM studies in Asians using qiime2 tools and found that Asians with Type 2 diabetes had different fecal bacterial compositions, co-abundance networks, and metagenome functions compared to healthy individuals.
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