Journal Article10.1016/j.vph.2024.107434
Different gene expression patterns between mouse and human brain pericytes revealed by single-cell/nucleus RNA sequencing
Yuyang Miao,Weihan Li,Marie Jeansson,Maarja Andaloussi Mäe,Lars Muhl,Liqun He +5 more
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TL;DR: This study compares gene expression patterns between mouse and human brain pericytes using single-cell/nucleus RNA sequencing, providing a comprehensive resource for understanding the translatability of mouse models in neurological disorders and neurodegenerative diseases research.
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Abstract: Pericytes in the brain play important roles for microvascular physiology and pathology and are affected in neurological disorders and neurodegenerative diseases. Mouse models are often utilized for pathophysiology studies of the role of pericytes in disease; however, the translatability is unclear as brain pericytes from mouse and human have not been systematically compared. In this study, we investigate the similarities and differences of brain pericyte gene expression between mouse and human. Our analysis provides a comprehensive resource for translational studies of brain pericytes.
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Citations
Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation.
17 Jul 2025
TL;DR: Pericytes in glioblastoma microenvironment exhibit region-specific phenotypic changes, with tumor-residing cells upregulating immune interactions and border-residing cells showing reduced activation, highlighting dynamic MC roles in GBM progression and immunosuppression.
References
Spatial reconstruction of single-cell gene expression data
TL;DR: Seurat is a computational strategy to infer cellular localization by integrating single-cell RNA-seq data with in situ RNA patterns, and correctly localizes rare subpopulations, accurately mapping both spatially restricted and scattered groups.
Pericytes regulate the blood–brain barrier
Annika Armulik,Guillem Genové,Maarja Mäe,Maya H. Nisancioglu,Elisabet Wallgard,Elisabet Wallgard,Colin Niaudet,Liqun He,Liqun He,Jenny Norlin,Per Lindblom,Karin Strittmatter,Karin Strittmatter,Bengt Johansson,Christer Betsholtz +14 more
TL;DR: A novel and critical role for pericytes is indicated in the integration of endothelial and astrocyte functions at the neurovascular unit, and in the regulation of the blood–brain barrier.
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Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
TL;DR: The history of investigations into pericytes, the mural cells of blood microvessels, are reviewed, emerging concepts are indicated, and problems and promise are pointed out.
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Pericytes are required for blood–brain barrier integrity during embryogenesis
TL;DR: Pericytes regulate functional aspects of the blood–brain barrier, including the formation of tight junctions and vesicle trafficking in CNS endothelial cells, but inhibit the expression of molecules that increase vascular permeability and CNS immune cell infiltration.
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A molecular atlas of cell types and zonation in the brain vasculature
Michael Vanlandewijck,Michael Vanlandewijck,Liqun He,Maarj A. Andaloussi Mäe,Johanna Andrae,Koji Ando,Francesca Del Gaudio,Khayrun Nahar,Thibaud Lebouvier,Thibaud Lebouvier,Bàrbara Laviña,Leonor Gouveia,Ying Sun,Elisabeth Raschperger,Markus Räsänen,Yvette Zarb,Naoki Mochizuki,Annika Keller,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +20 more
TL;DR: The transcriptional basis of the gradual phenotypic change along the arteriovenous axis is uncovered and unexpected cell type differences are revealed: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells.