Journal Article10.1007/BF02062018
Different expressions of sialyl Tn antigen between polypoid and flat-type early colorectal cancers
Atsushi Nanashima,Tohru Nakagoe,Terumitsu Sawai,Shiro Nakamura,Hiroyuki Yamaguchi,Toru Yasutake,Hiroyuki Kusano,Hiroyoshi Ayabe +7 more
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TL;DR: The results suggest that the low expression of STn antigen in flat-type cancers may be the result of different mechanisms of cellular transformation during carcinogenesis from the usual adenoma-carcinoma sequence in colorectal neoplasms.
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Abstract: PURPOSE: Sialyl Tn (STn) antigen is a cancer-associated carbohydrate antigen expressed in cancers of the digestive tract. We compared the proportion of specimens of flat-type colorectal cancers expressing STn with that of polypoid cancers, by examining the immunohistochemical reactivity of STn in various morphologic types of early and advanced colorectal cancers. METHODS; A total of 111 biopsies from the colorectal area were examined for STn expression, including 11 adenomas, 58 early cancers, and 42 advanced cancers. Each section was stained immunohistochemically for STn antigen. In each section, we examined STn expression in the cancer area, adjacent mucosa, and normal epithelium. RESULTS: STn expression was detected in 90.9 percent of adenomas, 36.2 percent of early cancers (T1), 64.3 percent of advanced cancers (>T1), and 52 percent of mucosa adjacent to cancer. The morphology of cancer tissue did not influence the number of specimens exhibiting STn antigen expression in mucosa adjacent to cancer cells. STn antigen was rarely expressed in flat or depressed-type early cancers (T1; 7.1 percent), and the expression was higher in moderately than in well-differentiated adenocarcinomas. In advanced cancers (>T1), a similar proportion of protruding and small ulcerative cancers expressed STn. CONCLUSION: Our results suggest that the low expression of STn antigen in flat-type cancers may be the result of different mechanisms of cellular transformation during carcinogenesis from the usual adenoma-carcinoma sequence in colorectal neoplasms.
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Citations
Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology
Elisabete Fernandes,Janine Sores,Sofia Cotton,Andreia F. Peixoto,Dylan Ferreira,Rui Freitas,Celso A. Reis,Lúcio Lara Santos,José Alexandre Ferreira +8 more
TL;DR: This review presents functional and clinical evidences supporting a reinvestigation of classical serological glycan biomarkers such as sialyl-Tn (STn) and sIALyl-Lewis A (SLeA) antigens from a tumor glycoproteomics perspective to hold unexplored value for patients' management in precision oncology settings.
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High serum concentrations of sialyl Tn antigen in carcinomas of the biliary tract and pancreas
Atsushi Nanashima,Hiroyuki Yamaguchi,Tohru Nakagoe,Seiji Matsuo,Yorihisa Sumida,Takashi Tsuji,Terumitsu Sawai,Eiichirou Yamaguchi,Toru Yasutake,Hiroyoshi Ayabe +9 more
TL;DR: Measurement of serum STn level may be potentially useful for the diagnosis of carcinomas of the biliary tract and pancreas, particularly when combined with other tumor markers such as CEA or CA19-9.
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SIALYL-Tn antigen distribution in Helicobacter pylori chronic gastritis in children: an immunohistochemical study.
TL;DR: It is concluded that STn can be identified in gastric cells of pediatric patients with HpCG and that this does not correlate with other mucosubtances markers, which could indicate that minimal intestinal metaplasia takes place in children with H pylori.
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Differences in sialyl-Tn antigen expression between keratoacanthomas and cutaneous squamous cell carcinomas.
TL;DR: Results indicate that sialyl‐Tn expression is not directly related to cell proliferation, but rather to cellular features of post‐mitotic cells, and that sia‐GalNAc‐O‐Ser/Thr may be linked to tumor regression, as seen in keratoacanthomas.
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Different Expression of Sialyl Tn Antigen between Polypoid and Nonpolypoid Growth Types of Advanced Colorectal Carcinoma
Tohru Nakagoe,Atsushi Nanashima,Terumitsu Sawai,Takashi Tuji,Eiichiro Yamaguchi,Masaaki Jibiki,Hiroyuki Yamaguchi,Toru Yasutake,Hiroyoshi Ayabe,Tatsuki Matuo,Yutaka Tagawa +10 more
TL;DR: The data suggest that the difference in sialyl Tn antigen expression between two kinds of tumor growth patterns of advanced colorectal carcinomas, PG type and NPG type, may reflect different biological behaviors during tumor progression.
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References
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Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer
Steven H. Itzkowitz,Mei Yuan,Carolyn K. Montgomery,Thomas Kjeldsen,Helio K. Takahashi,William L. Bigbee,Young S. Kim +6 more
TL;DR: Like T antigen, Tn and sialosyl-Tn are oncodevelopmental cancer-associated antigens in the colon and appear to be useful markers of poorly differentiated adenocarcinomas and mucinous carcinomas: two histological subsets that often fail to express other cancer- associated antIGens and that are often associated with a poor clinical outcome.
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Sialosyl-Tn : a novel mucin antigen associated with prognosis in colorectal cancer patients
Steven H. Itzkowitz,Elana J. Bloom,William A. Kokal,Gunnard Modin,Sen-itiroh Hakomori,Young S. Kim +5 more
TL;DR: It is concluded that sialosyl‐Tn expression is an independent predictor of poor prognosis in colon cancer, and therefore qualitative mucin alterations may reflect important differences in the biological behavior of these neoplasms.
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O-linked mucin-type glycoproteins in normal and malignant colon mucosa: Lack of T-antigen expression and accumulation of tn and sialosyl-Tn antigens in carcinomas
TL;DR: The data indicate an expression of O‐linked Tn and sialosyl‐Tn core structures in fetal and infantile colon and in colorectal carcinomas and in remote morphologically normal and abnormal crypts in colons from carcinoma patients.
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•Journal Article
Tumor-associated Sialylated Antigens Are Constitutively Expressed in Normal Human Colonic Mucosa
Shunichiro Ogata,Immanuel Ho,Anli Chen,Derek Dubois,Joseph Maklansky,Anil K. Singhal,Sen-itiroh Hakomori,Steven H. Itzkowitz +7 more
TL;DR: The same sialylated epitopes can be expressed in a tumor-associated fashion by different mechanisms in different gastrointestinal organs; in the colon, these antigens are constitutively expressed and O-acetylated, whereas in the upper gastrointestinal tract, they are rarely O- caches, suggesting that other mechanisms such as differences in glycosylation account for the cancer-associated expression.
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Small nonpolypoid carcinomas of the large intestine.
TL;DR: Two small carcinomas of the colon were examined, one an intramucosal carcinoma and the other a small carcinoma invading the submucosa, finding no adenomatous hyperplasia or polyps in the vicinity.
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