Journal Article10.1017/S0033291700036473
Dieting reduces plasma tryptophan and alters brain 5-ht function in women
TL;DR: It is suggested that dieting reduces the availability of circulating tryptophan for brain 5-HT synthesis, which may play a part in some of the psychological consequences of dieting, including the development of clinical eating disorders.
read more
Abstract: A three week low calorie diet significantly reduced both total plasma tryptophan and the ratio of tryptophan to competing amino acids in a group of 15 healthy volunteers. Despite a similar percentage weight loss the reduction in plasma tryptophan was greater in women than men. In addition, only in women was dieting associated with increased prolactin secretion following intravenous tryptophan, a measure of brain 5-hydroxytryptamine (5-HT) function. These results suggest that dieting reduces the availability of circulating tryptophan for brain 5-HT synthesis. Women appear more vulnerable than men both to this effect and to its consequences for brain 5-HT function. Altered brain 5-HT function may play a part in some of the psychological consequences of dieting, including the development of clinical eating disorders.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
New insights into symptoms and neurocircuit function of anorexia nervosa
TL;DR: New brain imaging technology provides insights into ventral and dorsal neural circuit dysfunction — perhaps related to altered serotonin and dopamine metabolism — that contributes to the puzzling symptoms found in people with eating disorders.
798
Neurobiology of anorexia and bulimia nervosa.
TL;DR: Findings in brain chemistry and neuroimaging are reviewed that shed new light on understanding the psychopathology of these difficult and frustrating disorders.
654
The Association Between Childhood Depression and Adulthood Body Mass Index
TL;DR: Depression during childhood is positively associated with BMI during adulthood, and duration of depression between childhood and adulthood also emerged as a predictor of adult BMI.
404
Food craving, dietary restraint and mood.
TL;DR: Food craving was found to be only weakly related to dietary restraint, but highly and significantly correlated with external eating, emotional eating and susceptibility to hunger, and dysphoric mood was prominent prior to the cravings themselves.
361
The bovine protein α-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress
C. R. Markus,Berend Olivier,Geert Panhuysen,J. van der Gugten,M. S. Alles,Adriaan Tuiten,Herman G.M. Westenberg,Durk Fekkes,H. F. Koppeschaar,E. E. H. F. de Haan +9 more
TL;DR: Testing whether alpha-lactalbumin, a whey protein with a high tryptophan content, may increase the plasma Trp-LNAA ratio and reduce depressive mood and cortisol concentrations in stress-vulnerable subjects under acute stress found it improved coping ability.
312
References
Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids
TL;DR: The main determinant of brain tryPTophan and serotonin concentrations does not appear to be plasma tryptophan alone, but the ratio of this amino acid to other plasma neutral amino acids that compete with it for uptake into the brain.
1.1K
Brain serotonin content: physiological dependence on plasma tryptophan levels.
TL;DR: Brain serotonin cocentrations at 1 p.m. were significantly elevated 1 hour after rats received a dose of L-tryptophan and plasma and brain tryptophan levels were elevated 10 to 60 minutes after the injection, but they never exceeded the concentrationis that occur nocturnally in untreated aninmals as result of their normal 24-hour rhythms.
1K
•Book
Anorexia Nervosa : A Multidimensional Perspective
Paul E. Garfinkel,David M. Garner +1 more
- 01 Dec 1982
817
Serotonin and appetite
TL;DR: Do results mean that some serotonin-containing neurones play a role in the natural regulatory system which serves to match an organism’s nutritional intake to its bodily requirements?
588