Journal Article10.1152/AJPENDO.00401.2011
Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function
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TL;DR: This is the first study to show that the abnormal sperm physiology resulting from obesity can be reversed through diet and exercise, even in the presence of ongoing obesity, suggesting that diet and lifestyle interventions could be a combined approach to target subfertility in overweight and obese men.
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Abstract: Male obesity is associated with reduced sperm motility and morphology and increased sperm DNA damage and oxidative stress; however, the reversibility of these phenotypes has never been studied. The...
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Citations
Origins of lifetime health around the time of conception: causes and consequences.
Tom P. Fleming,Adam J. Watkins,Miguel A. Velazquez,John C. Mathers,Andrew M. Prentice,Judith Stephenson,Mary Barker,Mary Barker,Richard Saffery,Chittaranjan S. Yajnik,Judith J. Eckert,Mark A. Hanson,Mark A. Hanson,Terrence Forrester,Peter D. Gluckman,Peter D. Gluckman,Keith M. Godfrey,Keith M. Godfrey +17 more
TL;DR: It is proposed that the evidence for periconceptional effects on lifetime health is now so compelling that it calls for new guidance on parental preparation for pregnancy, beginning before conception, to protect the health of offspring.
883
Lifestyle factors and reproductive health: taking control of your fertility
TL;DR: The present literature review encompasses multiple lifestyle factors and places infertility in context for the couple by focusing on both males and females, and aims to identify the roles that lifestyle factors play in determining reproductive status.
Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content
Tod Fullston,E. Maria C. Ohlsson Teague,Nicole O. Palmer,Miles J. DeBlasio,Megan Mitchell,Mark A. Corbett,Cristin G. Print,Julie A. Owens,Michelle Lane +8 more
TL;DR: Diet‐induced paternal obesity modulates sperm microRNA content and germ cell methylation status, which are potential signals that program offspring health and initiate the transmission of obesity and impaired metabolic health to future generations.
576
Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies
TL;DR: Male adherence to a healthy diet could improve semen quality and fecundability rates, but the associations summarized in the present review need to be confirmed with large prospective cohort studies and especially with well-designed RCTs.
424
Impact of obesity on male fertility, sperm function and molecular composition.
Nicole O. Palmer,Hassan W. Bakos,Tod Fullston,Michelle Lane +3 more
- 01 Oct 2012
TL;DR: This review will focus on how male obesity affects fertility and sperm quality with a focus on proposed mechanisms and the potential reversibility of these adverse effects.
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References
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Jacob C. Seidell
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TL;DR: It can be tentatively concluded that obesity is particularly common in women living in relatively poor conditions.
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Who laboratory manual for the examination of human semen and sperm‐cervical mucus interaction
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TL;DR: The upcoming WHO laboratory manual for the examination of human semen and sperm cervical mucus interaction is highly anticipated. It will be a valuable resource for individuals seeking comprehensive guidance on the subject.
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Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
TL;DR: It is shown that paternal high-fat-diet (HFD) exposure programs β-cell ‘dysfunction’ in rat F1 female offspring induces increased body weight, adiposity, impaired glucose tolerance and insulin sensitivity, and the first report in mammals of non-genetic, intergenerational transmission of metabolic sequelae of a HFD from father to offspring.
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Weight Loss, Exercise, or Both and Physical Function in Obese Older Adults
Dennis T. Villareal,Suresh Chode,Nehu Parimi,David R. Sinacore,Tiffany N. Hilton,Reina Armamento-Villareal,Nicola Napoli,Clifford Qualls,Krupa Shah +8 more
TL;DR: It is suggested that a combination of weight loss and exercise provides greater improvement in physical function than either intervention alone.
Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men.
Tina Kold Jensen,Anne-Maria Andersson,Niels Jørgensen,Anne-Grethe Andersen,Elisabeth Carlsen,Jørgen Holm Petersen,Niels E. Skakkebæk +6 more
TL;DR: High or low BMI was associated with reduced semen quality, and it remains to be seen whether the increasing occurrence of obesity in the Western world may contribute to an epidemic of poor semen quality registered in some of the same countries.
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