Diagnóstico e tratamento da hepatite B
TL;DR: Active immunization, using modern recombinant vaccines, are lately, the most important instrument of control of the infection caused by the hepatitis B virus.
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Abstract: A hepatite B constitui grave problema de saude publica. Estima-se que 350 milhoes de pessoas, ou seja, 5% da populacao mundial sejam portadores dessa virose. Admite-se que a infeccao evolui para a cura em 90% a 95% dos casos e para o estado de portador cronico nos restantes 5% a 10%; a infeccao persistente pode resultar tambem em cirrose, insuficiencia hepatica e carcinoma hepatocelular. O diagnostico de qualquer das formas clinicas da hepatite B realiza-se atraves de tecnicas sorologicas. Os medicos, hoje, possuem acesso a modernas tecnicas laboratoriais capazes de avaliar a carga viral, o indice de replicacao do agente infeccioso e a eficacia das novas medicacoes utilizadas. Varios agentes antivirais tem sido usados no tratamento dos individuos com hepatite cronica, como o interferon alfa, a lamivudina, o famciclovir, e o adefovir dipivoxil, entre outros. A imunizacao ativa utilizando as modernas vacinas recombinantes constitui, na atualidade, a arma mais importante no combate a infeccao pelo virus da hepatite B.
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Citations
Characterization of HBeAg-negative chronic hepatitis B in western Brazilian Amazonia
Flamir da Silva Victoria,Cintia Mara Costa de Oliveira,Marilu Barbieri Victoria,Cristian Barbieri Victoria,Luis Carlos de Lima Ferreira +4 more
TL;DR: The present study conducted with 55 patients native from western Brazilian Amazonia, who were HBV-DNA positive after seroconversion of HBeAg, to describe the clinical and molecular characteristics of patients who are chronic carriers of HBsAg.
Evaluation of the sorologic pre-selection for the hepatitis B virus marker (total anti-HBc) in candidates to blood donation in the state of Acre, 2002
Rita do Socorro Uchôa da Silva,Sandra Albuquerque Lima Ribeiro,Rodrigo Pinheiro Silveira,Milton dos Santos Freitas +3 more
TL;DR: Previous serum screening for hepatitis B among blood donation candidates is a viable alternative, since it reduces cost and increases transfusional safety, and Attracting female donors, youths and those who have higher education levels, would signify potential blood donors for HEMOACRE.
Cost-effectiveness of telbivudine versus lamivudine for chronic hepatitis B
TL;DR: In chronic hepatitis B lamvudine is a more cost-effective or even cost-saving strategy when compared with telbivudine, and also higher values of quality adjusted life years.
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Temporal trends in the detection rates of hepatitis B in the Santa Catarina State, Brazil.
TL;DR: There were two distinct and significant trends in detection rates of hepatitis B in Santa Catarina in the period from 2002 to 2009, and the southern and far-western regions had significant increases and significant decreases respectively.
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