Diagnostic morphology in multiple myeloma

TL;DR: The authors report on the various morphological aspects of PC that may occur in multiple myeloma and related disorders, and discuss about their clinical and pathophysiological significance.

TL;DR: Clinopathologic features of primary effusion lymphoma, a large cell non-Hodgkin lymphoma localized predominantly in body cavities and occasionally in extracavitary regions, are summarized.

TL;DR: Multiple myeloma is characterized by the neoplastic proliferation of a single clone of plasma cells engaged in the production of a monoclonal immunoglobulin that produces skeletal destruction that results in bone pain and fractures.

TL;DR: The objective of the current study was to examine ST masses in MM patients using FNA and to classify and determine the prognostic significance of MM in these lesions based on cytologic features.

TL;DR: This work describes the clinical presentation and diagnosis of multiple myeloma, as well as other disorders associated with paraproteinaemia, including Waldenstrom's macroglobulinaemia.

TL;DR: Serum protein electrophoresis should be performed for patients with unexplained sensorimotor peripheral neuropathy, carpal tunnel syndrome, nephrotic syndrome or renal insufficiency, cardiomyopathy or refractory congestive heart failure, orthostatic hypotension, or malabsorption, because these conditions are common in AL.

TL;DR: LI specific for the neoplastic plasma cells resulted in excellent discrimination of patients with active disease, and this technique is useful clinically.

TL;DR: It is suggested that karyotype is an independent prognostic factor in multiple myeloma and in the majority of patients with normal karyotypes the mitoses originated from contaminating normal bone marrow cells.