Journal Article10.1016/S0968-6053(05)80022-5
Diagnostic morphology in multiple myeloma
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TL;DR: The impact of morphology in both bone marrow biopsy and aspiration on the diagnostic and prognostic approach to MM, and on the planning of appropriate therapy, is emphasized.
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About: This article is published in Current Diagnostic Pathology. The article was published on 01 Dec 1995. The article focuses on the topics: Multiple myeloma & Bone marrow.
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Citations
The role of the bone marrow microenvironment in multiple myeloma.
H De Raeve,Karin Vanderkerken +1 more
TL;DR: New therapeutic agents target both the MM, as well as the interaction MM cell - BM microenviroment, which is responsible for the specific homing in the BM, the proliferation and survival of the MM cells, the resistance of MM cells to chemotherapy, the development of osteolysis, immunodeficiency and anaemia.
100
Plasma cell morphology in multiple myeloma and related disorders
B. Ribourtout,M. Zandecki +1 more
TL;DR: The authors report on the various morphological aspects of PC that may occur in multiple myeloma and related disorders, and discuss about their clinical and pathophysiological significance.
65
Primary Effusion Lymphoma
Sanjay S. Patel,Philip Xiao +1 more
TL;DR: Clinopathologic features of primary effusion lymphoma, a large cell non-Hodgkin lymphoma localized predominantly in body cavities and occasionally in extracavitary regions, are summarized.
41
Multiple Myeloma and Related Disorders
Robert A. Kyle
- 01 Jan 2001
TL;DR: Multiple myeloma is characterized by the neoplastic proliferation of a single clone of plasma cells engaged in the production of a monoclonal immunoglobulin that produces skeletal destruction that results in bone pain and fractures.
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Soft tissue masses in patients with multiple myeloma: a fine-needle aspiration study of 30 cases with flow cytometry and clinical correlation.
TL;DR: The objective of the current study was to examine ST masses in MM patients using FNA and to classify and determine the prognostic significance of MM in these lesions based on cytologic features.
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References
Plasma Cell Karyotype in Multiple Myeloma
TL;DR: The association of all t(8;14) abnormalities with IgA protein type suggested a pathogenetic relationship between a specific karyotypic abnormality and myeloma protein type.
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Monoclonal gammopathies of undetermined significance
TL;DR: The detection of monoclonal gammopathies is characterized by the proliferation of a single clone of plasma cells producing a homogeneous M-protein (M-protein, M-component, paraprotein).
179
Diagnostic criteria of multiple myeloma.
TL;DR: During long-term follow-up of patients with monoclonal gammopathy of undetermined significance, it was found that one fourth developed multiple myeloma or related disorders.
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Clinical, morphological, and cell kinetic differences among multiple myeloma, monoclonal gammopathy of undetermined significance, and smoldering multiple myeloma.
Philip R. Greipp,Robert A. Kyle +1 more
TL;DR: The plasma cell labeling index is a reliable diagnostic test when applied in cases of monoclonal gammopathy, especially when differentiation from MM is difficult using standard clinical criteria.
159
CALLA-positive myeloma: an aggressive subtype with poor survival.
TL;DR: CALLA positivity, as part of an immature B phenotype, was found to correlate with very aggressive clinical disease: median survival six months v 56 months for the CALLA-negative group.
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