Open AccessJournal Article
Diagnostic classification of psychiatric disorders and familial-genetic research.
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TL;DR: This paper looks at the difficulties posed by the criteria for schizophrenia as laid down in the International Classification of Diseases, 10th revision (ICD-10) and the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised (DSM-III-R), and highlights the discrepancies between the majority of diagnostic boundaries and the various phenotype aggregation patterns observed in family studies.
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Abstract: The validity of diagnostic definitions in psychiatry is directly related to the extent to which their etiology can be specified. However, since detailed knowledge of causal or susceptibility factors is lacking for most psychiatric disorders with a known or suspected familial-genetic origin, the current widely accepted classification systems largely fail to achieve this ideal. To illustrate this problem, this paper looks at the difficulties posed by the criteria for schizophrenia as laid down in the International Classification of Diseases, 10th revision (ICD-10) and the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised (DSM-III-R), and highlights the discrepancies between the majority of diagnostic boundaries and the various phenotype aggregation patterns observed in family studies. Progress in our understanding of psychiatric disorders requires to be firmly based on the findings of epidemiological studies as well as on a clear appreciation of the limitations of classification tools.
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References
Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders.
TL;DR: Data demonstrate a significant genetic contribution to unipolar depression and suicide and fail to disclose a significant contribution of family-associated transmission in the genesis of the mood disorders.
547
A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity
Richard E. Straub,C J MacLean,Francis A. O'Neill,J Burke,B Murphy,F Duke,R Shinkwin,Bradley T. Webb,J Zhang,Dermot Walsh +9 more
TL;DR: In 265 Irish pedigrees, with linkage analysis, evidence for a vulnerability locus for schizophrenia in region 6p24–22 is found, and this locus appears to influence the vulnerability to schizophrenia in roughly 15 to 30% of ourPedigrees.
474
Continuity and Discontinuity of Affective Disorders and Schizophrenia: Results of a Controlled Family Study
Wolfgang Maier,Dirk Lichtermann,Jürgen Minges,Joachim Hallmayer,R. Heun,Otto Benkert,Douglas F. Levinson +6 more
TL;DR: There could be a familial relationship between the predispositions to schizophrenia and to major depression, as suggested by a controlled family study of consecutive admissions.
401
•Journal Article
Heritable factors in the severity of affective illness.
TL;DR: A review of clinical experience with patients with primary affective disorder indicates that patients with a history characterized by recurrent depression interspersed with periods of hypomania (bipolar II) may have clinical courses that are distinguishable from bipolar I (depression with histories of mania) or unipolar patients.
362
Twin Concordance for DSM-III Schizophrenia: Scrutinizing the Validity of the Definition
TL;DR: DSM-III diagnoses were applied to 26 monozygotic and 34 dizygotic probands and their co-twins from the Maudsley Hospital schizophrenic series of Gottesman and Shields and both affective disorder and schizophrenia were found in genetically identical individuals.
286